Chromosoma

, Volume 115, Issue 4, pp 288–295

Cenp-F (mitosin) is more than a mitotic marker

Mini-Review

Abstract

Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein’s post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Asta Varis
    • 1
    • 2
  • Anna-Leena Salmela
    • 1
    • 3
  • Marko J. Kallio
    • 1
    • 2
  1. 1.Cancer Biology and Cell Screening DepartmentVTT Medical BiotechnologyTurkuFinland
  2. 2.Centre for BiotechnologyUniversity of TurkuTurkuFinland
  3. 3.Turku Graduate School of Biomedical SciencesUniversity of TurkuTurkuFinland

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