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Radiation interaction parameters for blood samples of breast cancer patients: an MCNP study

  • Ozan Toker
  • Mustafa Caglar
  • Ersoy Oz
  • Sezgin Bakirdere
  • Omer Topdagi
  • Onder Eyecioglu
  • Orhan IcelliEmail author
Original Article
  • 54 Downloads

Abstract

The main goal of this study was to determine radiation interaction parameters such as mass attenuation coefficients, effective atomic numbers, and effective electron densities depending on element concentrations (Na, K, Cu, Zn, Al, Ca, Mg Cr, Fe, Se) in blood samples of patients with breast cancer. Eighty blood samples were collected and analyzed in this study (40 from breast cancer patients and 40 from healthy patients). The determination of element concentrations of the samples was performed with inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-optical emission spectrometry (ICP-OES) after which the element concentrations were normalized to percentage. Mass attenuation coefficients were calculated by Monte Carlo simulation method. In addition, effective atomic numbers and effective electron density values of the blood samples were calculated with the ZXCOM program. One of the most important results of this study is that differences in radiation interaction parameters between the two groups were observed. More specifically, the mass attenuation coefficients of the healthy group’s blood samples were higher than those of the cancerous group at photon energies of 50 keV, 100 keV, 250 keV and 500 keV, while they were lower at 1 MeV. All the MCNP results were consistent with the results obtained from ZXCOM. As the main result of this study it is concluded that photon atomic parameters such as mass attenuation coefficient, effective atomic number and electron density may be considered in cancer diagnosis or treatment modalities.

Keywords

Breast cancer Monte Carlo MCNP Mass attenuation coefficient Electron density 

Notes

Funding

The author thanks the TUBITAK (2210C) and BAP Yildiz Technical University (2015-01-01-YL04, 832) for financial support.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Atatürk University Medical Faculty Ethics Committee, 10.24.2016, session 6, number: 22) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Ozan Toker
    • 1
  • Mustafa Caglar
    • 2
  • Ersoy Oz
    • 3
  • Sezgin Bakirdere
    • 4
  • Omer Topdagi
    • 5
  • Onder Eyecioglu
    • 6
  • Orhan Icelli
    • 1
    Email author
  1. 1.Department of PhysicsYildiz Technical UniversityIstanbulTurkey
  2. 2.Department of Medical Physicsİstanbul Medipol UniversityIstanbulTurkey
  3. 3.Department of StatisticsYildiz Technical UniversityIstanbulTurkey
  4. 4.Department of ChemistryYildiz Technical UniversityIstanbulTurkey
  5. 5.Department of MedicineAtatürk UniversityErzurumTurkey
  6. 6.Department of Computer EngineeringNisantasi UniversityIstanbulTurkey

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