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Radiation and Environmental Biophysics

, Volume 57, Issue 3, pp 205–214 | Cite as

Quantitative health impact of indoor radon in France

  • Roula Ajrouche
  • Candice Roudier
  • Enora CléroEmail author
  • Géraldine Ielsch
  • Didier Gay
  • Jérôme Guillevic
  • Claire Marant Micallef
  • Blandine Vacquier
  • Alain Le Tertre
  • Dominique Laurier
Original Article

Abstract

Radon is the second leading cause of lung cancer after smoking. Since the previous quantitative risk assessment of indoor radon conducted in France, input data have changed such as, estimates of indoor radon concentrations, lung cancer rates and the prevalence of tobacco consumption. The aim of this work was to update the risk assessment of lung cancer mortality attributable to indoor radon in France using recent risk models and data, improving the consideration of smoking, and providing results at a fine geographical scale. The data used were population data (2012), vital statistics on death from lung cancer (2008–2012), domestic radon exposure from a recent database that combines measurement results of indoor radon concentration and the geogenic radon potential map for France (2015), and smoking prevalence (2010). The risk model used was derived from a European epidemiological study, considering that lung cancer risk increased by 16% per 100 becquerels per cubic meter (Bq/m3) indoor radon concentration. The estimated number of lung cancer deaths attributable to indoor radon exposure is about 3000 (1000; 5000), which corresponds to about 10% of all lung cancer deaths each year in France. About 33% of lung cancer deaths attributable to radon are due to exposure levels above 100 Bq/m3. Considering the combined effect of tobacco and radon, the study shows that 75% of estimated radon-attributable lung cancer deaths occur among current smokers, 20% among ex-smokers and 5% among never-smokers. It is concluded that the results of this study, which are based on precise estimates of indoor radon concentrations at finest geographical scale, can serve as a basis for defining French policy against radon risk.

Keywords

Radon Lung cancer Health impact assessment 

Notes

Acknowledgements

We thank several researchers from Santé Publique France, including A. Lefranc, P. Beaudeau, A. Guillet, and P. de Crouy-Chanel.

Compliance with ethical standards

Conflict of interest

The authors declare they have no actual or potential competing financial interests.

Supplementary material

411_2018_741_MOESM1_ESM.docx (372 kb)
Supplementary material 1 (DOCX 371 KB)

References

  1. Ajrouche R, Ielsch G, Clero E, Roudier C, Gay D, Guillevic J, Laurier D, Le Tertre A (2017) Quantitative health risk assessment of indoor radon: a systematic review. Radiat Prot Dosim 177(1–2):69–77CrossRefGoogle Scholar
  2. Archer VE, Magnuson HJ, Holaday DA, Lawrence PA (1962) Hazards to health in uranium mining and milling. J Occup Med Off Publ Ind Med Assoc 4:55–60Google Scholar
  3. Axelsson G, Andersson EM, Barregard L (2015) Lung cancer risk from radon exposure in dwellings in Sweden: how many cases can be prevented if radon levels are lowered? Cancer Causes Control 26(4):541–547CrossRefGoogle Scholar
  4. Baysson H, Billon S, Laurier D, Rogel A, Tirmarche M (2003) Seasonal correction factors for estimating radon exposure in dwellings in France. Radiat Prot Dosim 104(3):245–252CrossRefGoogle Scholar
  5. Billon S, Morin A, Caer S, Baysson H, Gambard JP, Backe JC, Rannou A, Tirmarche M, Laurier D (2005) French population exposure to radon, terrestrial gamma and cosmic rays. Radiat Prot Dosim 113(3):314–320CrossRefGoogle Scholar
  6. Bochicchio F, Antignanmi S, Venoso G, Forastiere F (2013) Quantitative evaluation of the lung cancer deaths attributable to residential radon: a simple method and results for all the 21 Italian Regions. Radiat Meas 50:121–126CrossRefGoogle Scholar
  7. Bonaldi J, Andriantafika F, Chyderiotis S, Boussac-Zarebska M, Cao B, Benmarhnia T, Gremy I (2016) Les décès attribuables au tabagisme en France. Dernères estimations et tendance, années 2000 à 2013 [in French]. BEH 30–31:528–540Google Scholar
  8. Brand KP, Zielinski JM, Krewski D (2005) Residential radon in Canada: an uncertainty analysis of population and individual lung cancer risk. Risk Anal 25(2):253–269CrossRefGoogle Scholar
  9. Catelinois O, Rogel A, Laurier D, Billon S, Hemon D, Verger P, Tirmarche M (2006) Lung cancer attributable to indoor radon exposure in France: impact of the risk models and uncertainty analysis. Environ Health Perspect 114(9):1361–1366CrossRefGoogle Scholar
  10. Chen J, Moir D, Whyte J (2012) Canadian population risk of radon induced lung cancer: a re-assessment based on the recent cross-Canada radon survey. Radiat Prot Dosim 152(1–3):9–13CrossRefGoogle Scholar
  11. Cowppli-Bony A, Uhry Z, Remontret L, Guizard AV, Voirin N, Monnereau A, Bouvier AM, Colonna M, Bossard N, Woronoff AS, Grosclaude P (2016) Survie des personnes atteintes de cancer en France métropolitaine 1989–2013 [in French]. Institut de Veille Samitaire, Saint-MauriceGoogle Scholar
  12. Darby S, Hill D, Doll R (2001) Radon: a likely carcinogen at all exposures. Ann Oncol 12(10):1341–1351CrossRefGoogle Scholar
  13. Darby S, Hill D, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Deo H, Falk R, Forastiere F, Hakama M, Heid I, Kreienbrock L, Kreuzer M, Lagarde F, Makelainen I, Muirhead C, Oberaigner W, Pershagen G, Ruano-Ravina A, Ruosteenoja E, Rosario AS, Tirmarche M, Tomasek L, Whitley E, Wichmann HE, Doll R (2005) Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case–control studies. BMJ 330(7485):223CrossRefGoogle Scholar
  14. Darby S, Hill D, Deo H, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Falk R, Farchi S, Figueiras A, Hakama M, Heid I, Hunter N, Kreienbrock L, Kreuzer M, Lagarde F, Makelainen I, Muirhead C, Oberaigner W, Pershagen G, Ruosteenoja E, Rosario AS, Tirmarche M, Tomasek L, Whitley E, Wichmann HE, Doll R (2006) Residential radon and lung cancer—detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 persons without lung cancer from 13 epidemiologic studies in Europe. Scand J Work Environ Health 32(Suppl 1):1–83Google Scholar
  15. Demoury C, Ielsch G, Hemon D, Laurent O, Laurier D, Clavel J, Guillevic J (2013) A statistical evaluation of the influence of housing characteristics and geogenic radon potential on indoor radon concentrations in France. J Environ Radioact 126:216–225CrossRefGoogle Scholar
  16. EPA (2003) EPA assessment of risks from radon in homes. Environmental Protection Agency, WashingtonGoogle Scholar
  17. Gray A, Read S, McGale P, Darby S (2009) Lung cancer deaths from indoor radon and the cost effectiveness and potential of policies to reduce them. BMJ 338:a3110CrossRefGoogle Scholar
  18. Guignard R, Beck F, Richard J, Perreti-Watel P (2013) Le tabagisme en France. Analyse de l’enquête Baromètre santé 2010 Saint-Denis. Institut national de prévention et d’éducation pour la santé, ParisGoogle Scholar
  19. Ielsch G, Cushing ME, Combes P, Cuney M (2010) Mapping of the geogenic radon potential in France to improve radon risk management: methodology and first application to region Bourgogne. J Environ Radioact 101(10):813–820CrossRefGoogle Scholar
  20. Ielsch G, Warnery E, Pouchol C, Lajaunie C, Cale E, Wackernagel H (2015) Mapping of indoor radon and terrestrial gamma radiation levels in France: geostatistical modelling. In: 2nd international conference on radon in the environment, 25–29 May 2015, Krakow, PolandGoogle Scholar
  21. INCa (2014) Les cancers en France en 2014 Boulogne-Billancourt. InstituNational du Cancer, RockvilleGoogle Scholar
  22. Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS, Field RW, Klotz JB, Letourneau EG, Lynch CF, Lyon JI, Sandler DP, Schoenberg JB, Steck DJ, Stolwijk JA, Weinberg C, Wilcox HB (2005) Residential radon and risk of lung cancer: a combined analysis of 7 North American case–control studies. Epidemiology 16(2):137–145CrossRefGoogle Scholar
  23. Ledunois B, Drougard C (2016) Reglementation sur le radon en France et évolutions. In: Exposition au radon domestique, journée SFRP, 12 September 2016, Paris, FranceGoogle Scholar
  24. Lee HA, Lee WK, Lim D, Park SH, Baik SJ, Kong KA, Jung-Choi K, Park H (2015) Risks of lung cancer due to radon exposure among the regions of Korea. J Korean Med Sci 30(5):542–548CrossRefGoogle Scholar
  25. Leenhouts HP, Brugmans MJ (2001) Calculation of the 1995 lung cancer incidence in The Netherlands and Sweden caused by smoking and radon: risk implications for radon. Radiat Environ Biophys 40(1):11–21CrossRefGoogle Scholar
  26. Leuraud K, Schnelzer M, Tomasek L, Hunter N, Timarche M, Grosche B, Kreuzer M, Laurier D (2011) Radon, smoking and lung cancer risk: results of a joint analysis of three European case–control studies among uranium miners. Radiat Res 176(3):375–387ADSCrossRefGoogle Scholar
  27. Lubin J, Boice JJ, Edling C, Hornung R, Howe G, Kunz E (1994) Radon and lung cancer risk: a joint analysis of 11 underground miners studies. National Institutes of Health, Bethesda, pp 94–3644Google Scholar
  28. Lubin JH, Wang ZY, Boice JD Jr, Xu ZY, Blot WJ, De Wang L, Kleinerman RA (2004) Risk of lung cancer and residential radon in China: pooled results of two studies. Int J Cancer 109(1):132–137CrossRefGoogle Scholar
  29. Menzler S, Piller G, Gruson M, Rosario AS, Wichmann HE, Kreienbrock L (2008) Population attributable fraction for lung cancer due to residential radon in Switzerland and Germany. Health Phys 95(2):179–189CrossRefGoogle Scholar
  30. Milner J, Shrubsole C, Das P, Jones B, Ridley I, Chalabi Z, Hamilton I, Armstrong B, Davies M, Wilkinson P (2014) Home energy efficiency and radon related risk of lung cancer: modelling study. BMJ 348:f7493CrossRefGoogle Scholar
  31. NRC (National Research Council) (1999) BEIR VI - Health effects of exposure to radon. National Academy Press, Washington, DCGoogle Scholar
  32. Parkin DM (2011) 1. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer 105(Suppl 2):S2–S5CrossRefGoogle Scholar
  33. Pesch B, Kendzia B, Gustavsson P, Jockel KH, Johnen G, Pohlabeln H, Olsson A, Ahrens W, Gross IM, Bruske I, Wichmann HE, Merletti F, Richiardi L, Simonato L, Fortes C, Siemiatycki J, Parent ME, Consonni D, Landi MT, Caporaso N, Zaridze D, Cassidy A, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Stucker I, Fabianova E, Dumitru RS, Bencko V, Foretova L, Janout V, Rudin CM, Brennan P, Boffetta P, Straif K, Bruning T (2012) Cigarette smoking and lung cancer-relative risk estimates for the major histological types from a pooled analysis of case–control studies. Int J Cancer 131(5):1210–1219CrossRefGoogle Scholar
  34. Peterson E, Aker A, Kim J, Li Y, Brand K, Copes R (2013) Lung cancer risk from radon in Ontario, Canada: how many lung cancers can we prevent? Cancer Causes Control 24(11):2013–2020CrossRefGoogle Scholar
  35. Pruss-Ustun A, Mathers C, Corvolan C, Woodward A (2003) Introduction and methods: assessing the environmental burden of disease at national and local levels. World Health Organization, GenevaGoogle Scholar
  36. Steindorf K, Lubin J, Wichmann HE, Becher H (1995) Lung cancer deaths attributable to indoor radon exposure in West Germany. Int J Epidemiol 24(3): 485–492Google Scholar
  37. Veloso B, Nogueira JR, Cardoso MF (2012) Lung cancer and indoor radon exposure in the north of Portugal—an ecological study. Cancer Epidemiol 36(1):e26–e32CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Roula Ajrouche
    • 1
    • 2
  • Candice Roudier
    • 2
  • Enora Cléro
    • 1
    Email author
  • Géraldine Ielsch
    • 1
  • Didier Gay
    • 1
  • Jérôme Guillevic
    • 1
  • Claire Marant Micallef
    • 3
  • Blandine Vacquier
    • 2
  • Alain Le Tertre
    • 2
  • Dominique Laurier
    • 1
  1. 1.Institute for Radiological Protection and Nuclear SafetyFontenay-aux-Roses CedexFrance
  2. 2.Santé Publique FranceSaint-Maurice CedexFrance
  3. 3.International Agency for Research on CancerLyon Cedex 08France

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