Uranium distribution in broiler organs and possibilities for protection
- 164 Downloads
The aim of the present study was to investigate the distribution of uranium (uranyl nitrate hexahydrate, UN) in muscle and organs (kidney, liver, and brain) of broilers, after a 7-day contamination with UN and administration of two different adsorbents (organobentonite and organozeolite). The birds were contaminated during 7 days with 25 mg/UN per day. Adsorbents were given via gastric tube, immediately after contamination with UN. In group 1 that did not receive any adsorbents, histopathological changes in the contaminated broilers were observed in small intestine, liver, and kidney in the form of necrosis of intestinal villi, oedema and cytoplasmic vacuolation of hepatocytes, and dystrophic changes in the kidney tubules epithelium. Organobentonite administered via gastric tube (group 2) reduced uranium distribution by 66 % in kidney, 81 % in liver, and 34 % in brain. In group 3, administration of organozeolite reduced uranium distribution by 67 % in kidney, 68 % in liver, and 49 % in brain. In groups 2 and 3, where the broilers received adsorbents immediately after the UN contamination, no histopathological lesions were observed.
KeywordsUranium Toxicity Broilers Adsorbents Organobentonite Organozeolite
This work was supported by the Ministry of Education, Science and Technological Development of Serbia, in the frame of Project Nos. 31003 and 34103.
- Arruda-Neto JDT, Manso MV, Nogueira GP, Taricano ID, Saiki M, Zamboni CB, Bonamin LV, Camargo SP, Cestari AC, Deppman A, Garcia F, Gouveia AN, Guzman F, Helene OAM, Jorge SAC, Likhachev VP, Martins MN, Mesa J, Rodriguez O, Vanin VR (2004) Long-term accumulation and microdistribution of uranium in bone and marrow of beagle dogs. Int J Radiat Biol 80(8):565–575CrossRefGoogle Scholar
- Gilman AP, Villeneuve DC, Secours VE, Yagminas AP, Tracy BL, Quinn JM, Valli VE, Willes RJ, Moss MA (1998c) Uranyl nitrate: 28-day and 91-day toxicity studies in the Sprague-Dawley rat. Toxicol Sci 41:117–128Google Scholar
- Haley DP, Bulger R, Dobyan DC (1982) The long-term effects of uranyl nitrate on the structure and function of the rat kidney. Virchows Arch (Cell Pathol) 41:181–192Google Scholar
- International Commission for Radiation Protection (ICRP) (1996) International Commission for Radiation Protection. Age-dependent doses to members of the public from intake of radionuclides: Part 4 inhalation dose coefficients. Publication 72 Annals of the ICRP Pergamon Press, Oxford, UKGoogle Scholar
- National Research Council (NRC) (2008) Committee on toxicologic and radiologic effects from exposure to depleted uranium during and after combat committee on toxicology. Review of toxicologic and radiologic risks to military personnel from exposure to depleted uranium during and after combat. The National Academies Press, Washington, DC. Available at: http://www.nap.edu/catalog/11979.html
- Oguz H (2011) A review from experimental trials on detoxification of aflatoxin in poultry feed. Eurasian J Vet Sci 27(1):1–12Google Scholar
- Rizzi L, Simioli M, Roncada P, Zaghini A (2003) Aflatoxin B1 and clinoptilolite in feed for laying hens: effects on egg quality mycotoxin residues in livers and hepatic mixed-function oxygenase activities. J Food Prot 66:860–865Google Scholar
- Slavata B, Vitorović G (2004) Radiocesium binders—AFCF and clinoptilolite efficiency testing in broiler chicken exposed to alimentary contamination with 137Cs. Acta Vet 54(5–6):437–446Google Scholar
- Vitorović G, Slavata B, Stošić K, Mladenović V, Vitorović D (2002) The effect of clinoptilolite on 137Cs binding in broiler chickens. Agric Food Sci Finl 11:137–141Google Scholar