Radiation and Environmental Biophysics

, Volume 50, Issue 3, pp 339–344

Scanning irradiation device for mice in vivo with pulsed and continuous proton beams

  • Christoph Greubel
  • Walter Assmann
  • Christian Burgdorf
  • Günther Dollinger
  • Guanghua Du
  • Volker Hable
  • Alexander Hapfelmeier
  • Ralf Hertenberger
  • Peter Kneschaurek
  • Dörte Michalski
  • Michael Molls
  • Sabine Reinhardt
  • Barbara Röper
  • Stefan Schell
  • Thomas E. Schmid
  • Christian Siebenwirth
  • Tatiana Wenzl
  • Olga Zlobinskaya
  • Jan J. Wilkens
Original Paper

Abstract

A technical set-up for irradiation of subcutaneous tumours in mice with nanosecond-pulsed proton beams or continuous proton beams is described and was successfully used in a first experiment to explore future potential of laser-driven particle beams, which are pulsed due to the acceleration process, for radiation therapy. The chosen concept uses a microbeam approach. By focusing the beam to approximately 100 × 100 μm2, the necessary fluence of 109 protons per cm2 to deliver a dose of 20 Gy with one-nanosecond shot in the Bragg peak of 23 MeV protons is achieved. Electrical and mechanical beam scanning combines rapid dose delivery with large scan ranges. Aluminium sheets one millimetre in front of the target are used as beam energy degrader, necessary for adjusting the depth–dose profile. The required procedures for treatment planning and dose verification are presented. In a first experiment, 24 tumours in mice were successfully irradiated with 23 MeV protons and a single dose of 20 Gy in pulsed or continuous mode with dose differences between both modes of 10%. So far, no significant difference in tumour growth delay was observed.

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Christoph Greubel
    • 1
  • Walter Assmann
    • 2
  • Christian Burgdorf
    • 1
  • Günther Dollinger
    • 1
  • Guanghua Du
    • 3
  • Volker Hable
    • 1
  • Alexander Hapfelmeier
    • 4
  • Ralf Hertenberger
    • 2
  • Peter Kneschaurek
    • 5
  • Dörte Michalski
    • 5
  • Michael Molls
    • 5
  • Sabine Reinhardt
    • 2
  • Barbara Röper
    • 5
  • Stefan Schell
    • 5
  • Thomas E. Schmid
    • 5
  • Christian Siebenwirth
    • 3
  • Tatiana Wenzl
    • 5
  • Olga Zlobinskaya
    • 5
  • Jan J. Wilkens
    • 5
  1. 1.Institut für Angewandte Physik und Messtechnik (LRT2)Universität der Bundeswehr MünchenNeubibergGermany
  2. 2.Fakultät für PhysikLudwig-Maximilians-Universität MünchenGarchingGermany
  3. 3.Physik Department E12Technische Universität MünchenGarchingGermany
  4. 4.Institut für Medizinische Statistik und EpidemiologieTechnische Universität MünchenMünchenGermany
  5. 5.Klinik für Strahlentherapie und Radiologische OnkologieTechnische Universität MünchenMünchenGermany

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