Radiation and Environmental Biophysics

, Volume 49, Issue 3, pp 463–468 | Cite as

The European strategy on low dose risk research and the role of radiation quality according to the recommendations of the “ad hoc” High Level and Expert Group (HLEG)

  • Mauro Belli
  • Andrea Ottolenghi
  • Wolfgang Weiss
Short Communication


Health effects of exposures at low doses and/or low dose rates are recognized as requiring intensive research activity to answer several questions. To address these issues at a strategic level in Europe, with the perspective of integrating national and EC efforts (in particular those within the Euratom research programmes), a “European High Level and Expert Group (HLEG) on low dose risk research” was formed and carried out its work during 2008. The Group produced a report published by the European Commission in 2009 and available on the website The more important research issues identified by the HLEG were as follows: (a) the shape of dose–response for cancer; (b) the tissue sensitivities for cancer induction; (c) the individual variability in cancer risk; (d) the effects of radiation quality (type); (e) the risks from internal radiation exposure; and (f) the risks of, and dose response relationships for, non-cancer diseases. In this paper, the radiation quality issues are especially considered, since they are closely linked to health problems and related radioprotection in space and in emerging radiotherapeutic techniques (i.e., hadrontherapy). The peculiar features of low-fluence, high-LET radiation exposures can question in particular the validity of the radiation-weighting factor (w R ) approach. Specific strategies are therefore needed to assess such risks. A multi-scale/systems biology approach, based on mechanistic studies coordinated with molecular-epidemiological studies, is considered essential to elucidate differences and similarities between specific effects of low- and high-LET radiation.


Linear Energy Transfer Radiation Quality Galactic Cosmic Radiation Protracted Exposure Strategic Research Agenda 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Several parts of this paper reproduce or are based on the HLEG report. The authors would like to acknowledge the following HLEG composition. Formative members: W Weiss (BfS, Germany, chair), M Belli (ISS, Italy), G.N Kelly (EC), P. Legrain (CEA, France), J. Repussard (IRSN, France), S. Salomaa (STUK, Finland), H. Walker (DH, United Kingdom);Co-opted experts: M. Atkinson (HMGU, Germany), E. Cardis (CREAL, Spain), R. Cox (HPA, United Kingdom), A. Elliot (NHS, United Kingdom), J. Hall (Institut Curie, France), M. Harms-Ringdahl (Stockholm University, Sweden), J-R. Jourdain (IRSN, France), A. Ottolenghi (Pavia University, Italy); Technical support for the Secretariat: D.T. Goodhead. At the first stage of the work M.H. Barcellos-Hoff provided useful information about the US DOE Low Dose Program.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Mauro Belli
    • 1
    • 2
  • Andrea Ottolenghi
    • 3
    • 4
  • Wolfgang Weiss
    • 5
  1. 1.Istituto Superiore di SanitàRomeItaly
  2. 2.INFN Sezione Roma-gr.coll.SanitàRomeItaly
  3. 3.Dipartimento di Fisica Nucleare e TeoricaUniversità di PaviaPaviaItaly
  4. 4.INFN Sezione di PaviaPaviaItaly
  5. 5.Bundesamt für StrahlenschutzNeuherbergGermany

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