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Radiation and Environmental Biophysics

, Volume 49, Issue 3, pp 317–324 | Cite as

Tissue and data archives from irradiation experiments conducted at Argonne National Laboratory over a period of four decades

  • Qiong Wang
  • Tatjana Paunesku
  • Gayle Woloschak
Review

Abstract

Irradiation experiments conducted on dogs and mice at Argonne National Laboratory, IL between 1952 and 1992 led to creation of archives of paraffin-embedded tissues accompanied by extensive datasets with gross pathology and histopathology information. Over the past 40 years, these data were investigated computationally, using different statistical approaches. Embedded tissues are used to this day as a source of genomic and mitochondrial DNA for quantitative PCR amplification. Data and paraffin block sections are available upon request—interested researchers should visit the Websites http://janus.northwestern.edu/dog_tissues/introduction.php for dog and http://janus.northwestern.edu/janus2/index.php for mouse archive.

Keywords

Dose Rate Aplastic Anemia Amifostine Argonne National Laboratory Relative Biological Effectiveness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by United States Department of Energy grants DE-FG02-04ER63920, DE-FG02-05ER64086 and DE-FG02-05ER64100/A000.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Qiong Wang
    • 1
    • 2
  • Tatjana Paunesku
    • 1
  • Gayle Woloschak
    • 1
  1. 1.Department of Radiation Oncology, Feinberg School of MedicineNorthwestern UniversityChicagoUSA
  2. 2.Cancer Center of the Affiliated Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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