Radiation and Environmental Biophysics

, Volume 46, Issue 2, pp 173–177 | Cite as

Relative effectiveness of different particles and energies in disrupting behavioral performance

  • B. M. Rabin
  • B. Shukitt-Hale
  • J. A. Joseph
  • K. L. Carrihill-Knoll
  • A. N. Carey
  • V. Cheng
Proceedings of the 4th IWSRR


On exploratory class missions to other planets, astronauts will be exposed to varieties and doses of heavy particles, which are not experienced in low earth orbit. These particles can affect neurobehavioral function and potentially interfere with the ability of astronauts to successfully meet mission requirements. While a significant amount of research has been performed on the relative biological effectiveness (RBE) of different types of heavy particles on cytogenetic function, little research has been done on the effectiveness of different particles on central nervous system function and on cognitive/behavioral performance. The present paper reviews some recent research on the effects of exposure to different types and energies of heavy particles on the performance of two behavioral tasks which depend upon the integrity of the central dopaminergic system. This review indicates that the RBE of different particles for neurobehavioral dysfunction cannot be predicted only on the basis of the linear energy transfer of the specific particle.


  1. 1.
    Cucinotta FA, Schimmerling W, Saganti PB, Wilson JW, Peterson LE, Badhwar GD, Dicello JF (2001) Space radiation cancer risks and uncertainties for Mars missions. Radiat Res 156:682–688CrossRefGoogle Scholar
  2. 2.
    Edwards AA (2001) RBE of radiations in space and the implications for space travel. Phys Med 27(suppl 1):147–152Google Scholar
  3. 3.
    Schimmerling W, Cucinotta FA, Wilson JW (2003) Radiation risk and human space exploration. Adv Space Res 31:27–34CrossRefADSGoogle Scholar
  4. 4.
    Ainsworth EJ (1986) Early and late mammalian responses to heavy charged particles. Adv Space Res 6:153–165CrossRefADSGoogle Scholar
  5. 5.
    Blakely EA, Kronenberg A (1998) Heavy-ion radiobiology: New approaches to delineate mechanisms underlying enhanced biological effectiveness. Radiat Res 150(suppl):S126–S145CrossRefGoogle Scholar
  6. 6.
    Brooks AL, Bao S, Rithidech K, Couch LA, Braby LA (2001) Relative effectiveness of HZE iron-56 particles for the induction of cytogenetic damage in vivo. Radiat Res 155(2):353–359CrossRefGoogle Scholar
  7. 7.
    Rabin BM, Hunt WA, Joseph JA (1989) An assessment of the behavioral toxicity of high-energy iron particles compared to other qualities of radiation. Radiat Res 119:113–122CrossRefGoogle Scholar
  8. 8.
    Rabin BM, Hunt WA, Joseph JA, Dalton TK, Kandasamay SB (1991) Relationship between linear energy transfer and behavioral toxicity in rats following exposure to protons and heavy particles. Radiat Res 128:216–221CrossRefGoogle Scholar
  9. 9.
    Gauger GE, Tobias CA, Tang T, Whitney M (1986) The effect of space radiation of the nervous system. Adv Space Res 6:243–249CrossRefADSGoogle Scholar
  10. 10.
    Rabin BM, Joseph JA, Erat S (1998) Effects of exposure to different types of radiation on behaviors mediated by peripheral or central systems. Adv Space Res 22:217–225CrossRefADSGoogle Scholar
  11. 11.
    Rabin BM, Joseph JA, Shukitt-Hale B, McEwen J (2000) Effects of exposure to heavy particles on a behavior mediated by the central nervous system. Adv Space Res 25:2065–2074CrossRefADSGoogle Scholar
  12. 12.
    Rabin BM, Joseph JA, Shukitt-Hale B (2004) Heavy particle irradiation, neurochemistry and behavior: thresholds, dose–response curves and recovery of function. Adv Space Res 33:1330–1333CrossRefADSGoogle Scholar
  13. 13.
    Rabin BM, Hunt WA, Lee J (1983) Attenuation of radiation- and drug-induced conditioned taste aversions following area postrema lesions in the rat. Radiat Res 93:388–394CrossRefGoogle Scholar
  14. 14.
    Lindner MD, Plone MA, Francis JM, Blaney TJ, Salmone JD, Emerich DF (1997) Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed-ratio bar pressing task. Behav Brain Res 86:25–40CrossRefGoogle Scholar
  15. 15.
    Rabin BM, Buhler LL, Joseph JA, Shukitt-Hale B, Jenkins DG (2002) Effects of exposure to 56Fe particles or protons on fixed-ratio operant responding in rats. J Rad Res 43(suppl):S225–S228CrossRefGoogle Scholar
  16. 16.
    Cucinotta FA, Nikjoo H, Goodhead DT (1998) The effects of delta rays on the number of particle-track traversals per cell in laboratory and space exposures. Radiat Res 150:115–119CrossRefGoogle Scholar
  17. 17.
    Cucinotta FA, Durante M (2006) Cancer risk from exposure to cosmic rays: implications for space exploration by human beings. Lancet Oncol 7:431–435CrossRefGoogle Scholar
  18. 18.
    Kraft G, Scholz M, Bechthold U (1999) Tumor therapy and track structure. Radiat Environ Biophys 98:229–237CrossRefGoogle Scholar
  19. 19.
    Durante M, George K, Gialenella G, Grossi G, La Tessa C, Manti L, Miller J, Pugliese M, Scampoli P, Cucinotta FA (2005) Cytogenetic effects of high energy iron ions: dependence on shielding thickness and material. Radiat Res 164:571–576CrossRefGoogle Scholar
  20. 20.
    Kronenberg A, Gauny S, Criddle K, Vannais D, Ueno A, Kraemer S, Waldre CA, (1995) Heavy ion mutagenesis: linear energy transfer effects and genetic linkage. Radiat Environ Biophys 34:73–78CrossRefGoogle Scholar
  21. 21.
    Wilson JW, Cucinotta FA, Miller J, Shinn JL, Thibeault SA, Singleterry RS, Simonsen LC, Kim MH (2001) Approach and issues related to shield material design to protect astronauts from space radiation. Mater Des 22:541–554Google Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • B. M. Rabin
    • 1
  • B. Shukitt-Hale
    • 2
  • J. A. Joseph
    • 2
  • K. L. Carrihill-Knoll
    • 1
  • A. N. Carey
    • 2
  • V. Cheng
    • 2
  1. 1.Department of PsychologyUMBCBaltimoreUSA
  2. 2.Human Nutrition Research Center on AgingUSDA-ARS, Tufts UniversityBostonUSA

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