Advertisement

Radiation and Environmental Biophysics

, Volume 45, Issue 3, pp 179–185 | Cite as

Human biokinetics of strontium—part II: Final data evaluation of intestinal absorption and urinary excretion of strontium in human subjects after stable tracer administration

  • Vera Höllriegl
  • Wei Bo Li
  • Uwe Oeh
Original Paper

Abstract

Fractional intestinal absorption (f 1 value) and urinary excretion of strontium in healthy human volunteers has been measured by simultaneous oral and intravenous administration of the stable isotopes 86Sr and 84Sr using the double-isotope method. Final evaluation of the complete data set confirmed that ingestion of different foodstuff and nutritional factors could influence the fractional gut uptake of strontium. In some cases, significant deviations from the f 1 value adopted by the International Commission on Radiological Protection (ICRP) were found. The arithmetic mean (± standard deviation) of the f 1 values of all experiments performed was determined to be 0.46 (± 0.24). The probability distribution function of the f 1 values is represented by a lognormal curve with a geometric mean of 0.38 and a geometric standard deviation of 2.06. Urinary excretion in all subjects varied depending on the administered foodstuff in a wide range and differs from the ICRP model, up to 2 days after tracer administration. No age or gender dependence of the absorbed strontium fraction and of the urinary excretion of strontium after an oral load was found.

Keywords

Alginate Strontium Urinary Excretion 86Sr Thermal Ionization Mass Spectrometry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors would like to thank Dr. Augusto Giussani (University of Milano, Department of Physics, I-20133 Milano, Italy) for valuable contributions and discussions, as far as the excretion data are concerned.

References

  1. 1.
    Turnlund JR (1989) The uses of stable isotopes in mineral nutrition research. J Nutr 119:7–14Google Scholar
  2. 2.
    Werner E, Roth P, Höllriegl V, Hansen C, Kaltwasser JP, Giussani A, Cantone MC, Greim H, Zilker T, Felgenhauer N (2002) Assessment of intestinal absorption of trace metals in humans by means of stable isotopes. Isotopes Environ Health Stud 38:23–31CrossRefGoogle Scholar
  3. 3.
    ICRP (1994) Age dependent doses to members of the public from intake of radionuclides. Part 2. Ingestion dose coefficients. International Commission on Radiological Protection. Publication 67 Pergamon Press, OxfordGoogle Scholar
  4. 4.
    Werner E, Hansen Ch, Roth P, McAughey J, Haines J (1995) Assessment of intestinal absorption (f1 values) of strontium for aqueous solutions and foodstuffs. In: Van Kaick G (ed) Health effects of internally deposited radionuclides. World Scientific, Singapore, p 113Google Scholar
  5. 5.
    Höllriegl V, Louvat P, Werner E, Roth P, Schramel P, Wendler I, Felgenhauer N, Zilker T (2002) Studies of strontium biokinetics in humans. Part 2: Uptake of strontium from aqueous solutions and labelled foodstuffs. Radiat Environ Biophys 41:281–287Google Scholar
  6. 6.
    Höllriegl V, Li WB, Oeh U, Roth P (2006) Methods for assessing gastrointestinal absorption of strontium in humans by stable tracer techniques. Health Phys 90:232–240CrossRefGoogle Scholar
  7. 7.
    Li WB, Höllriegl V, Roth P, Oeh U (2006) Human biokinetics of strontium. Part I Intestinal absorption rate and its impact on dose coefficient of 90Sr after ingestion. Radiat Environ Biophys 45:115–124CrossRefGoogle Scholar
  8. 8.
    DeGracia JA, Ivanovich P, Fellows H, Rich C (1965) A double isotope method for measurements of intestinal absorption of calcium in man. J Lab Clin Med 66:822–829Google Scholar
  9. 9.
    Höllriegl V, Werner E, Roth P, Schramel P, Wendler I (2002) Studies of strontium biokinetics in humans. Part 1. Optimisation of intrinsic labelling of foodstuffs with stable isotopes of strontium. Radiat Environ Biophys 41:179–183Google Scholar
  10. 10.
    Höllriegl V, Röhmuß M, Oeh U, Roth P (2004) Strontium biokinetics in humans: Influence of alginate on the uptake of ingested strontium. Health Phys 86:193–196CrossRefGoogle Scholar
  11. 11.
    Höllriegl V, Röhmuß M, Oeh U, Werner E, Roth P (2004) Reduction in the absorption of dietary strontium in man by nutritional factors. In: Proceedings of IRPA 11, 23–28.5.2004, Madrid, SENDA, ISBN 84–87078-05-2Google Scholar
  12. 12.
    Sips AJAM, Van Der Vijgh WJF (1994) Strontium. In: Seiler HG, Sigel A, Sigel H (eds) Handbook on metals in clinical and analytical chemistry. Marcel Dekker, New York, p 577Google Scholar
  13. 13.
    Spencer H, Lewin I, Samachson J (1967) Influence of dietary and hormonal factors on radiostrontium metabolism in man. In: Lenihan JMA, Loutit JF, Martin JH. Strontium metabolism. Academic, London, p. 111Google Scholar
  14. 14.
    McAughey JJ, Vernon L, Haines J, Sanders T, Clark R (1994) Fractional gut absorption of strontium, barium and neodymium following administration of stable isotope tracers. In: Proceedings of the 9th international conference on heavy metals in the environment, TorontoGoogle Scholar
  15. 15.
    Apostoaei AJ (2002) Absorption of strontium from the gastrointestinal tract into plasma in healthy human adults. Health Phys 83:56–65CrossRefGoogle Scholar
  16. 16.
    Sutton A (1967) Reduction of strontium absorption in man by the addition of alginate to the diet. Nature 216:1005–1007CrossRefADSGoogle Scholar
  17. 17.
    Apostoaei AJ (2001) Determination of the uncertainties in radiation doses from ingestion of 90Sr. Ph.D. Thesis University of Tennessee, Knoxville, TNGoogle Scholar
  18. 18.
    Fujita M, Yabe A, Ueno K, Oshino M, Okuyama N (1963) The behaviour of strontium-85 in a normal man following a single ingestion-absorption and excretion. Health Phys 9:407–415Google Scholar
  19. 19.
    Hesp R, Ramsbottom B (1965) Effect of sodium alginate in inhibiting uptake of radiostrontium by the human body. Nature 208:1341–1342CrossRefADSGoogle Scholar
  20. 20.
    Likhtarev IA, Dobroskok IA, Ilyin LA, Kransnoschekova GP, Likhtareva TM, Smirnov BI, Sobolev EP, Shamov VP, Shapiro EL (1975) A study of certain characteristics of strontium metabolism in a homogeneous group of human subjects. Health Phys 28:49–60CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.GSF-National Research Center for Environment and HealthInstitute of Radiation ProtectionNeuherbergGermany

Personalised recommendations