Advertisement

Lung

, Volume 197, Issue 1, pp 113–114 | Cite as

Role of Antigen Type in Survival in Chronic Hypersensitivity Pneumonitis

  • Traci N. AdamsEmail author
  • Chad A. Newton
  • Craig S. Glazer
LETTER TO THE EDITOR

Hypersensitivity pneumonitis (HP) is a group of granulomatous, interstitial, bronchiolar, and alveolar-filling pulmonary diseases caused by repeated exposure and sensitization to a variety of antigens, the most common of which are avian and mold exposure [1]. Prior studies report conflicting results with regard to the effect of antigen type on survival in HP [2, 3, 4]. To evaluate whether history of avian or mold exposure is associated with clinical outcomes, we evaluated a retrospective cohort of patients with a multidisciplinary diagnosis of HP for an association between avian or mold exposure and overall and transplant-free survival. We also evaluated the diagnostic yield of bronchoscopy in these patients in order to assess for lead-time bias as a possible confounder.

We conducted a retrospective cohort study of all patients with a MDD diagnosis of HP at a single center between 2007 and 2017 as previously described [1]. We identified antigen exposure through a detailed history. We...

Notes

Funding

The study was funded by the Grant Nos. NCATS KL2TR001103 (CAN), UL1TR001105 (CAN, TA), and 5 T32 HL098040-08 (TA).

Compliance with Ethical Standards

Conflict of interest

The authors have no conflicts of interest to report.

References

  1. 1.
    Adams TN et al (2018) Utility of bronchoalveolar lavage and transbronchial biopsy in patients with hypersensitivity pneumonitis. Lung 196(5):617–622CrossRefGoogle Scholar
  2. 2.
    Fernandez Perez ER et al (2013) Identifying an inciting antigen is associated with improved survival in patients with chronic hypersensitivity pneumonitis. Chest 144(5):1644–1651CrossRefGoogle Scholar
  3. 3.
    Hanak V et al (2008) High-resolution CT findings of parenchymal fibrosis correlate with prognosis in hypersensitivity pneumonitis. Chest 134(1):133–138CrossRefGoogle Scholar
  4. 4.
    Vourlekis JS et al (2004) The effect of pulmonary fibrosis on survival in patients with hypersensitivity pneumonitis. Am J Med 116(10):662–668CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care MedicineUniversity of Texas Southwestern Medical CenterDallasUSA

Personalised recommendations