, Volume 197, Issue 1, pp 101–103 | Cite as

Thoracic Air-Leak Syndrome Complicating Allogeneic Hematopoietic Stem-Cell Transplantation

  • Tiara Boghanim
  • Marlène Murris
  • Tatiana Lamon
  • Anne Huynh
  • Julien Mazières
  • Charles-Hugo Marquette
  • Alain DidierEmail author


We report a case of thoracic air-leak syndrome, an extremely rare complication developed after an episode of organizing pneumonia due to graft-vs-host disease in a 19-year-old male. This unusual non-infectious pulmonary complication occurred 527 days after allogeneic HSCT and led to the patient’s death within 1 month due to cardio-respiratory failure. Herein, we highlight chest-imaging aspects which are typical. Early detection by high-resolution chest CT could improve patient management.


Pneumothorax Pneumomediastinum Air-leak Allogeneic hematopoietic stem-cell transplantation Graft-versus-host disease 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained from parents because the person described in the case report has died.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Pôle des Voies RespiratoiresHôpital Larrey, CHU de ToulouseToulouse Cedex 09France
  2. 2.Service d’hématologieCHU ToulouseToulouseFrance
  3. 3.Hôpital Pasteur and Institute for Research on Cancer and Ageing (IRCAN) (Inserm U10181/UMR CNRS 7284)University Nice Sophia AntipolisNiceFrance

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