Prognosis of Cancer with Synchronous or Metachronous Malignant Pleural Effusion
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Malignant pleural effusions (MPE) may either coincide with or follow the diagnosis of a primary tumor. Whether this circumstance influences prognosis has not been well substantiated.
Retrospective review of all consecutive patients who were cared for at a Spanish university hospital during an 11-year period and received a diagnosis of MPE.
Of 401 patients, the MPE was the first evidence of cancer in 265 (66%), and it followed a previously diagnosed neoplasm in 136 (34%). Lung cancer predominated in the former group (131, 50%), and breast cancer in the latter (55, 40%). MPE that were the presenting manifestation of hematological and ovarian tumors had a statistically significant survival advantage as compared to those which developed in patients from a previously known cancer (respective absolute differences of 41 and 20 months; p < 0.005).
In hematological and ovarian malignancies, the synchronous or metachronous diagnosis of MPE may have prognostic implications.
KeywordsMalignant pleural effusion Lung cancer Breast cancer Ovarian cancer Lymphoma Survival Pleural procedures
Compliance with Ethical Standards
Conflict of interest
There are no conflicts of interest with the current study.
All studies performed in human participants were in accordance with the ethical standards of the institutional research committee and with the Helsinki declaration.
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