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Lung

, Volume 193, Issue 6, pp 933–938 | Cite as

Survival in Patients with Advanced Non-cystic Fibrosis Bronchiectasis Versus Cystic Fibrosis on the Waitlist for Lung Transplantation

  • Don HayesJr.Email author
  • Benjamin T. Kopp
  • Joseph D. Tobias
  • Frederick W. Woodley
  • Heidi M. Mansour
  • Dmitry Tumin
  • Stephen E. Kirkby
Article

Abstract

Background

Survival in non-cystic fibrosis (CF) bronchiectasis is not well studied.

Methods

The United Network for Organ Sharing database was queried from 1987 to 2013 to compare survival in adult patients with non-CF bronchiectasis to patients with CF listed for lung transplantation (LTx). Each subject was tracked from waitlist entry date until death or censoring to determine survival differences between the two groups.

Results

Of 2112 listed lung transplant candidates with bronchiectasis (180 non-CF, 1932 CF), 1617 were used for univariate Cox and Kaplan–Meier survival function analysis, 1173 for multivariate Cox models, and 182 for matched-pairs analysis based on propensity scores. Compared to CF, patients with non-CF bronchiectasis had a significantly lower mortality by univariate Cox analysis (HR 0.565; 95 % CI 0.424, 0.754; p < 0.001). Adjusting for potential confounders, multivariate Cox models identified a significant reduction in risk for death associated with non-CF bronchiectasis who were lung transplant candidates (HR 0.684; 95 % CI 0.475, 0.985; p = 0.041). Results were consistent in multivariate models adjusting for pulmonary hypertension and forced expiratory volume in one second.

Conclusions

Non-CF bronchiectasis with advanced lung disease was associated with significantly lower mortality hazard compared to CF bronchiectasis on the waitlist for LTx. Separate referral and listing criteria for LTx in non-CF and CF populations should be considered.

Keywords

Bronchiectasis Cystic fibrosis Non-cystic fibrosis Survival 

Notes

Author Contribution

Don Hayes, Jr. contributed in conception and design, acquisition of data, interpretation of data, drafting of the manuscript. Benjamin T. Kopp contributed in conception and design, interpretation of data, revision of the manuscript. Joseph D. Tobias contributed in conception and design, interpretation of data, revision of the manuscript. Frederick W. Woodley contributed in conception and design, interpretation of data, revision of the manuscript. Heidi M. Mansour contributed in conception and design, interpretation of data, revision of the manuscript. Dmitry Tumin contributed in analysis of data, interpretation of data, revision of the manuscript. Stephen Kirkby contributed in conception and design, interpretation of data, revision of the manuscript.

Compliance with Ethical Standards

Conflict of interest

The authors report no conflicts of interest and have no relevant disclosures regarding this manuscript.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Don HayesJr.
    • 1
    • 2
    • 3
    • 5
    Email author
  • Benjamin T. Kopp
    • 1
    • 5
  • Joseph D. Tobias
    • 4
    • 6
  • Frederick W. Woodley
    • 1
    • 7
  • Heidi M. Mansour
    • 8
  • Dmitry Tumin
    • 1
    • 6
  • Stephen E. Kirkby
    • 1
    • 2
    • 5
  1. 1.Department of Pediatrics, Nationwide Children’s HospitalThe Ohio State UniversityColumbusUSA
  2. 2.Department of Internal MedicineThe Ohio State UniversityColumbusUSA
  3. 3.Department of SurgeryThe Ohio State UniversityColumbusUSA
  4. 4.Department of AnesthesiologyThe Ohio State UniversityColumbusUSA
  5. 5.Section of Pulmonary MedicineNationwide Children’s HospitalColumbusUSA
  6. 6.Department of Anesthesiology and Pain MedicineNationwide Children’s HospitalColumbusUSA
  7. 7.Section of Gastroenterology, Hepatology, and NutritionNationwide Children’s HospitalColumbusUSA
  8. 8.Skaggs Center of Pharmaceutical SciencesThe University of ArizonaTucsonUSA

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