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Lung

, Volume 193, Issue 6, pp 919–926 | Cite as

Ten-Year Survival in Patients with Idiopathic Pulmonary Fibrosis After Lung Transplantation

  • Liesbeth ten KloosterEmail author
  • George D. Nossent
  • Johanna M. Kwakkel-van Erp
  • Diana A. van Kessel
  • Erik J. Oudijk
  • Ed A. van de Graaf
  • Bart Luijk
  • Rogier A. Hoek
  • Bernt van den Blink
  • Peter Th. van Hal
  • Erik A. Verschuuren
  • Wim van der Bij
  • Coline H. van Moorsel
  • Jan C. Grutters
Article

Abstract

Introduction

Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The purpose of this study was to evaluate trajectory data of IPF patients listed for LTX and to investigate the survival after LTX.

Methods and Results

Data were retrospectively collected from September 1989 until July 2011 of all IPF patients registered for LTX in the Netherlands. Patients were included after revision of the diagnosis based on the criteria set by the ATS/ERS/JRS/ALAT. Trajectory data, clinical data at time of screening, and donor data were collected. In total, 98 IPF patients were listed for LTX. During the waiting list period, 30 % of the patients died. Mean pulmonary artery pressure, 6-min walking distance, and the use of supplemental oxygen were significant predictors of mortality on the waiting list. Fifty-two patients received LTX with a median overall survival after transplantation of 10 years.

Conclusions

This study demonstrated a 10-year survival time after LTX in IPF. Furthermore, our study demonstrated a significantly better survival after bilateral LTX in IPF compared to single LTX although bilateral LTX patients were significantly younger.

Keywords

Interstitial lung diseases Usual interstitial pneumonia Organ transplantation Outcomes 

Notes

Compliance with Ethical Standards

Conflict of interest

None of the authors has a financial relationship with a commercial entity that has an interest in the subject of the presented manuscript or other conflicts of interest to disclose.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Liesbeth ten Klooster
    • 1
    Email author
  • George D. Nossent
    • 4
  • Johanna M. Kwakkel-van Erp
    • 2
  • Diana A. van Kessel
    • 1
    • 2
  • Erik J. Oudijk
    • 1
    • 2
  • Ed A. van de Graaf
    • 2
  • Bart Luijk
    • 2
  • Rogier A. Hoek
    • 3
  • Bernt van den Blink
    • 3
  • Peter Th. van Hal
    • 3
  • Erik A. Verschuuren
    • 4
  • Wim van der Bij
    • 4
  • Coline H. van Moorsel
    • 1
    • 2
  • Jan C. Grutters
    • 1
    • 2
  1. 1.Department of Pulmonology, Center of Interstitial Lung DiseasesSt. Antonius HospitalNieuwegeinThe Netherlands
  2. 2.Division of Heart and LungsUniversity Medical Center UtrechtUtrechtThe Netherlands
  3. 3.Department of Respiratory MedicineErasmus MCRotterdamThe Netherlands
  4. 4.Department of Pulmonary Medicine and TuberculosisUniversity of Groningen, University Medical Center GroningenGroningenThe Netherlands

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