Serum Surfactant Protein D (SP-D) is a Prognostic Marker of Poor Outcome in Patients with A/H1N1 Virus Infection
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Surfactant protein D (SP-D) plays an important role in the innate responses against pathogens and its production is altered in lung disorders.
We studied the circulating levels of SP-D in 37 patients with acute respiratory distress syndrome due to the A/H1N1 virus infection and in 40 healthy controls. Cox logistic regression models were constructed to explore the association of SP-D levels and risk of death.
Mortality rate after a 28-day was 32.42 %. Significant higher levels of SP-D were detected in A/H1N1 patients with fatal outcome (p < 0.05). After adjusting for confounding variables, levels of SP-D ≥250 ng/mL were associated with increased the risk of death (HR = 8.27, 95 % CI 1.1–64.1, p = 0.043).
Our results revealed that higher circulating levels of SP-D are associated with higher mortality risk in critically ill A/H1N1 patients. SP-D might be a predictive factor of poor outcomes in viral pneumonia.
KeywordsSurfactant protein D (SP-D) A/H1N1 virus Influenza ARDS Mortality Biomarker
The authors thanks to the patients for their participation in this study. This study was supported by a Grant No. 127002 of the “Fondo Sectorial de Investigación en Salud y Seguridad Social” (FOSISSS) from the National Council of Science and Technology of Mexico (CONACYT).
Conflict of interest
The authors declare that they have no conflict of interest.
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