Lung

, Volume 192, Issue 4, pp 525–532

ADAM33 Gene Polymorphisms are Associated with the Risk of Idiopathic Pulmonary Fibrosis

  • Soo-Taek Uh
  • An-Soo Jang
  • Sung-Woo Park
  • Jong-Sook Park
  • Chang-Gi Min
  • Yong Hoon Kim
  • Byung-Lae Park
  • Hyoung Doo Shin
  • Dong Soon Kim
  • Choon-Sik Park
Article

Abstract

Background

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea and worsening lung function due to remodeling of the lung, including epithelial mesenchymal transition. ADAM33 is a disintegrin and metalloprotease domain-containing protein, which may be related to lung fibrosis by exerting angiogenesis and remodeling of the lung. Thus, we evaluated the association of single-nucleotide polymorphisms (SNPs) of ADAM33 with the risk of IPF.

Methods

A total of 237 patients with IPF and 183 healthy subjects participated in the present study. Nine polymorphisms were selected. Genotyping was performed by single-base extension. Polymorphisms and haplotypes were analyzed for associations with the risk of IPF using multiple logistic regression models controlling for age, gender, and smoking status as covariates.

Results

All SNPs were in Hardy-Weinberg equilibrium. The minor allele frequency (MAF) of rs628977G>A in intron 21 was significantly lower in subjects with surgical IPF than in normal controls in the recessive model [33.2 vs. 38.0 %, p = 0.02, OR = 0.40 (0.19–0.84)]. When the subjects with clinical IPF were included, the difference in MAF persisted with a p value of 0.03 [OR = 0.50 (0.27–0.94)].

Conclusions

ADAM33 rs628977G>A was marginally associated with a decreased risk of IPF in a recessive model.

Keywords

ADAM33 Protein Single nucleotide polymorphisms Genotype Idiopathic pulmonary fibrosis 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Soo-Taek Uh
    • 1
  • An-Soo Jang
    • 2
  • Sung-Woo Park
    • 2
  • Jong-Sook Park
    • 2
  • Chang-Gi Min
    • 2
  • Yong Hoon Kim
    • 3
  • Byung-Lae Park
    • 4
  • Hyoung Doo Shin
    • 4
    • 5
  • Dong Soon Kim
    • 6
  • Choon-Sik Park
    • 2
    • 7
  1. 1.Division of Allergy and Respiratory MedicineSoonchunhyang University HospitalSeoulSouth Korea
  2. 2.Genome Research Center for Allergy and Respiratory DiseaseSoonchunhyang University Bucheon HospitalBucheonSouth Korea
  3. 3.Division of Respiratory MedicineSoonchunhyang UniversityChunanSouth Korea
  4. 4.Department of Genetic EpidemiologySNP-Genetics Inc.SeoulSouth Korea
  5. 5.Department of Life ScienceSogang UniversitySeoulSouth Korea
  6. 6.Division of Pulmonary and Critical Care Medicine, Asan Medical CenterUniversity of UlsanSeoulSouth Korea
  7. 7.Division of Allergy and Respiratory Medicine, Department of Internal MedicineSoonchunhyang University Bucheon HospitalBucheonSouth Korea

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