Dust is in the Air. Part II: Effects of Occupational Exposure to Welding Fumes on Lung Function in a 9-Year Study
- 451 Downloads
- 8 Citations
Abstract
Purpose
Adverse health effects of work-related contact with respirable hazardous substances are of great public interest. Because related prospective and long-term follow-up studies are rare, the extent of acute and chronic pulmonary health risks of occupational exposure to welding fumes is discussed controversially in the scientific literature. The objective of the present longitudinal study during a 9-year period was to investigate the annual changes of lung function in welders.
Methods
Anthropometric measures and smoking behaviour, and spirometric tests (FVC, FEV1, and MEF50) obtained during routine occupational health checkups of female and male workers (n = 1,982) in Austria during the years 2002–2010 were analyzed.
Results
The study participants displayed average lung function values lower than the age- and sex-specific norm. Decrease in respiratory capacity was dependent on smoking habits and duration of occupational exposure. Specifically for welders (n = 1,326), decrease of pulmonary function was significantly associated with heavy smoking (FVC −70.7 ml, p = 0.07; FEV1 −167.4 ml, p < 0.001; MEF50 −356.2 ml/s, p < 0.001), but not with moderate smoking habits, and also with duration of occupational exposure to welding fumes per year (FVC −0.89 ml, p = 0.36; FEV1 −2.91 ml, p < 0.001; MEF50 −4.7 ml/s, p = 0.047).
Conclusions
Individual smoking habits as well as duration of occupational exposure to welding fumes showed a negative impact on lung function parameters. To reduce the risk of work-associated respiratory morbidity, smoking cessation is highly recommended to personnel engaged in welding fumes- and dust-exposed occupations.
Keywords
Chronic obstructive pulmonary disease (COPD) Smoking Spirometry Occupational exposure Welding fumesNotes
Conflict of interest
None declared.
References
- 1.Hannu T, Piipari R, Tuppurainen M, Nordman H, Tuomi T (2007) Occupational asthma caused by stainless steel welding fumes: a clinical study. Eur Respir J 29(1):85–90. doi: 10.1183/09031936.00058106 CrossRefPubMedGoogle Scholar
- 2.Baur X, Bakehe P, Vellguth H (2012) Bronchial asthma and COPD due to irritants in the workplace—an evidence-based approach. J Occup Med Toxicol 7(1):19. doi: 10.1186/1745-6673-7-19 PubMedCentralCrossRefPubMedGoogle Scholar
- 3.Wang ZP, Larsson K, Malmberg P, Sjogren B, Hallberg BO, Wrangskog K (1994) Asthma, lung function, and bronchial responsiveness in welders. Am J Ind Med 26(6):741–754CrossRefPubMedGoogle Scholar
- 4.Brand P, Gube M, Gerards K, Bertram J, Kaminski H, John AC, Kuhlbusch T, Wiemann M, Eisenbeis C, Winkler R, Kraus T (2010) Internal exposure, effect monitoring, and lung function in welders after acute short-term exposure to welding fumes from different welding processes. J Occup Environ Med 52(9):887–892. doi: 10.1097/JOM.0b013e3181f09077 CrossRefPubMedGoogle Scholar
- 5.Ould-Kadi F, Nawrot TS, Hoet PH, Nemery B (2007) Respiratory function and bronchial responsiveness among industrial workers exposed to different classes of occupational agents: a study from Algeria. J Occup Med Toxicol 2:11. doi: 10.1186/1745-6673-2-11 PubMedCentralCrossRefPubMedGoogle Scholar
- 6.El-Zein M, Malo JL, Infante-Rivard C, Gautrin D (2003) Incidence of probable occupational asthma and changes in airway calibre and responsiveness in apprentice welders. Eur Respir J 22(3):513–518CrossRefPubMedGoogle Scholar
- 7.Beckett WS, Pace PE, Sferlazza SJ, Perlman GD, Chen AH, Xu XP (1996) Airway reactivity in welders: a controlled prospective cohort study. J Occup Environ Med 38(12):1229–1238CrossRefPubMedGoogle Scholar
- 8.Szram J, Schofield SJ, Cosgrove MP, Cullinan P (2012) Welding, longitudinal lung function decline and chronic respiratory symptoms: a systematic review of cohort studies. Eur Respir J. doi: 10.1183/09031936.00206011 PubMedGoogle Scholar
- 9.Hochgatterer K, Moshammer H, Haluza D (2013) Dust is in the air: effects of occupational exposure to mineral dust on lung function in a 9-year study. Lung. doi: 10.1007/s00408-013-9463-7 Google Scholar
- 10.Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J (2005) Standardisation of spirometry. Eur Respir J 26(2):319–338. doi: 10.1183/09031936.05.00034805 CrossRefPubMedGoogle Scholar
- 11.Verordnung des Bundesministers für Arbeit und Soziales über die Gesundheitsüberwachung am Arbeitsplatz (2006) BGBl.II Nr. 27/1997. http://www.arbeitsinspektion.gv.at/NR/rdonlyres/34C0CE01-9934-417D-8562-6F95C2790409/0/VGUE.pdf. Accessed 25 April 2011
- 12.Loukzadeh Z, Sharifian SA, Aminian O, Shojaoddiny-Ardekani A (2009) Pulmonary effects of spot welding in automobile assembly. Occup Med (Lond) 59(4):267–269. doi: 10.1093/occmed/kqp033 CrossRefGoogle Scholar
- 13.Luo JC, Hsu KH, Shen WS (2006) Pulmonary function abnormalities and airway irritation symptoms of metal fumes exposure on automobile spot welders. Am J Ind Med 49(6):407–416. doi: 10.1002/ajim.20320 CrossRefPubMedGoogle Scholar
- 14.Bhumika N, Prabhu GV, Ferreira AM, Kulkarni MK, Vaz FS, Singh Z (2012) Respiratory morbidity among welders in the shipbuilding industry, Goa. Indian J Occup Environ Med 16(2):63–65. doi: 10.4103/0019-5278.107069 PubMedCentralCrossRefPubMedGoogle Scholar
- 15.Thaon I, Demange V, Herin F, Touranchet A, Paris C (2012) Increased lung function decline in blue-collar workers exposed to welding fumes. Chest 142(1):192–199. doi: 10.1378/chest.11-0647 CrossRefPubMedGoogle Scholar
- 16.Erkinjuntti-Pekkanen R, Slater T, Cheng S, Fishwick D, Bradshaw L, Kimbell-Dunn M, Dronfield L, Pearce N (1999) Two-year follow-up of pulmonary function values among welders in New Zealand. J Occup Environ Med 56(5):328–333CrossRefGoogle Scholar
- 17.Meo SA, Azeem MA, Subhan MM (2003) Lung function in Pakistani welding workers. J Occup Environ Med 45(10):1068–1073. doi: 10.1097/01.jom.0000085889.16029.6b CrossRefPubMedGoogle Scholar
- 18.Christensen SW, Bonde JP, Omland O (2008) A prospective study of decline in lung function in relation to welding emissions. J Occup Med Toxicol 3:6. doi: 10.1186/1745-6673-3-6 PubMedCentralCrossRefPubMedGoogle Scholar
- 19.Jayawardana P, Abeysena C (2009) Respiratory health of welders in a container yard, Sri Lanka. Occup Med (Lond) 59(4):226–229. doi: 10.1093/occmed/kqn166 CrossRefGoogle Scholar
- 20.Ozdemir O, Numanoglu N, Gonullu U, Savas I, Alper D, Gurses H (1995) Chronic effects of welding exposure on pulmonary function tests and respiratory symptoms. Occup Environ Med 52(12):800–803PubMedCentralCrossRefPubMedGoogle Scholar
- 21.Antonini JM, Lewis AB, Roberts JR, Whaley DA (2003) Pulmonary effects of welding fumes: review of worker and experimental animal studies. Am J Ind Med 43(4):350–360. doi: 10.1002/ajim.10194 CrossRefPubMedGoogle Scholar
- 22.Oh JH, Yang MJ, Heo JD, Yang YS, Park HJ, Park SM, Kwon MS, Song CW, Yoon S, Yu IJ (2012) Inflammatory response in rat lungs with recurrent exposure to welding fumes: a transcriptomic approach. Toxicol Ind Health 28(3):203–215. doi: 10.1177/0748233711410906 CrossRefPubMedGoogle Scholar
- 23.Flynn MR, Susi P (2010) Manganese, iron, and total particulate exposures to welders. J Occup Environ Hyg 7(2):115–126. doi: 10.1080/15459620903454600 CrossRefPubMedGoogle Scholar
- 24.Hobson A, Seixas N, Sterling D, Racette BA (2011) Estimation of particulate mass and manganese exposure levels among welders. Ann Occup Hyg 55(1):113–125. doi: 10.1093/annhyg/meq069 PubMedCentralCrossRefPubMedGoogle Scholar
- 25.Mansouri N, Atbi F, Moharamnezhad N, Rahbaran DA, Alahiari M (2008) Gravimetric and analytical evaluation of welding fume in an automobile part manufacturing factory. J Res Health Sci 8(2):1–8PubMedGoogle Scholar
- 26.Hoffmeyer F, Raulf-Heimsoth M, Lehnert M, Kendzia B, Bernard S, Berresheim H, Duser M, Henry J, Weiss T, Koch HM, Pesch B, Bruning T (2012) Impact of different welding techniques on biological effect markers in exhaled breath condensate of 58 mild steel welders. J Toxicol Environ Health A 75(8–10):525–532. doi: 10.1080/15287394.2012.675303 CrossRefPubMedGoogle Scholar
- 27.Berlinger B, Benker N, Weinbruch S, L’Vov B, Ebert M, Koch W, Ellingsen DG, Thomassen Y (2011) Physicochemical characterisation of different welding aerosols. Anal Bioanal Chem 399(5):1773–1780. doi: 10.1007/s00216-010-4185-7 CrossRefPubMedGoogle Scholar
- 28.Subhashree AR, Shanthi B, Parameaswari PJ (2013) The red cell distribution width as a sensitive biomarker for assessing the pulmonary function in automobile welders—a cross sectional study. J Clin Diagn Res 7(1):89–92. doi: 10.7860/JCDR/2012/5051.2678 PubMedCentralPubMedGoogle Scholar
- 29.Hoffmeyer F, Raulf-Heimsoth M, Weiss T, Lehnert M, Gawrych K, Kendzia B, Harth V, Henry J, Pesch B, Bruning T (2012) Relation between biomarkers in exhaled breath condensate and internal exposure to metals from gas metal arc welding. J Breath Res 6(2):027105. doi: 10.1088/1752-7155/6/2/027105 CrossRefPubMedGoogle Scholar