, Volume 191, Issue 4, pp 441–443 | Cite as

Interstitial Lung Disease in a Child with Antisynthetase Syndrome

  • Don HayesJr.Email author
  • Peter B. Baker
  • Heidi M. Mansour
  • Mark E. Peeples
  • Kathleen K. Nicol



Antisynthetase Syndrome is associated with interstitial lung disease in adult patients, but this has not been described in children.

Materials and methods

A 13-year-old with interstitial lung disease due to Antisynthetase Syndrome and pulmonary arterial hypertension underwent emergent bilateral lung transplantation after a rapid clinical decline.


We present the clinical, radiographic, and histological findings of a child with interstitial lung disease due to Antisynthetase Syndrome.


Antisynthetase syndrome Anti-Jo-1 antibody Child Interstitial lung disease 


Conflict of interest

The authors have no conflict of interest or disclosures related to any companies or organizations whose products or services discussed in this manuscript.


  1. 1.
    Watanabe K, Handa T, Tanizawa K, Hosono Y, Taguchi Y, Noma S, Kobashi Y, Kubo T, Aihara K, Chin K, Nagai S, Mimori T, Mishima M (2011) Detection of antisynthetase syndrome in patients with idiopathic interstitial pneumonias. Respir Med 105(8):1238–1247PubMedCrossRefGoogle Scholar
  2. 2.
    Yousem SA, Gibson K, Kaminski N, Oddis CV, Ascherman DP (2010) The pulmonary histopathologic manifestations of the anti-Jo-1 tRNA synthetase syndrome. Mod Pathol 23(6):874–880PubMedCrossRefGoogle Scholar
  3. 3.
    Tillie-Leblond I, Wislez M, Valeyre D, Crestani B, Rabbat A, Israel-Biet D, Humbert M, Couderc LJ, Wallaert B, Cadranel J (2008) Interstitial lung disease and anti-Jo-1 antibodies: difference between acute and gradual onset. Thorax 63(1):53–59PubMedCrossRefGoogle Scholar
  4. 4.
    Marie I, Hachulla E, Chérin P, Dominique S, Hatron PY, Hellot MF, Devulder B, Herson S, Levesque H, Courtois H (2002) Interstitial lung disease in polymyositis and dermatomyositis. Arthritis Rheum 47(6):614–622PubMedCrossRefGoogle Scholar
  5. 5.
    Marguerie C, Bunn CC, Beynon HL, Bernstein RM, Hughes JM, So AK, Walport MJ (1990) Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes. Q J Med 77(282):1019–1038PubMedCrossRefGoogle Scholar
  6. 6.
    Nishikai M, Reichlin M (1980) Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis. Characterization of the Jo-1 antibody system. Arthritis Rheum 23(8):881–888PubMedCrossRefGoogle Scholar
  7. 7.
    Vázquez-Abad D, Rothfield NF (1996) Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis. Arthritis Rheum 39(2):292–296PubMedCrossRefGoogle Scholar
  8. 8.
    Yoshida S, Akizuki M, Mimori T, Yamagata H, Inada S, Homma M (1983) The precipitating antibody to an acidic nuclear protein antigen, the Jo-1, in connective tissue diseases. A marker for a subset of polymyositis with interstitial pulmonary fibrosis. Arthritis Rheum 26(5):604–611PubMedCrossRefGoogle Scholar
  9. 9.
    Nadrous HF, Pellikka PA, Krowka MJ, Swanson KL, Chaowalit N, Decker PA, Ryu JH (2005) Pulmonary hypertension in patients with idiopathic pulmonary fibrosis. Chest 128(4):2393–2399PubMedCrossRefGoogle Scholar
  10. 10.
    Andersen CU, Mellemkjær S, Hilberg O, Nielsen-Kudsk JE, Simonsen U, Bendstrup E (2012) Pulmonary hypertension in interstitial lung disease: prevalence, prognosis and 6 min walk test. Respir Med 106(6):875–882PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Don HayesJr.
    • 1
    Email author
  • Peter B. Baker
    • 2
  • Heidi M. Mansour
    • 3
  • Mark E. Peeples
    • 1
  • Kathleen K. Nicol
    • 2
  1. 1.Department of PediatricsThe Ohio State University College of Medicine, Nationwide Children’s HospitalColumbusUSA
  2. 2.Department of PathologyThe Ohio State University College of Medicine, Nationwide Children’s HospitalColumbusUSA
  3. 3.Department of Pharmaceutical SciencesUniversity of Kentucky College of PharmacyLexingtonUSA

Personalised recommendations