Obstructive Sleep Apnea Syndrome: Blood Viscosity, Blood Coagulation Abnormalities, and Early Atherosclerosis
- 802 Downloads
Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for atherosclerosis and arterial thrombosis, which are associated with high cardiovascular (CV) morbidity and mortality. In studies performed in clinical populations with elevated CV event risk profiles, the occurrence of moderate to severe OSAS was very often accompanied by a worsened vascular function and increased prevalence of structural abnormalities. Recent investigations of atherosclerosis in OSAS have focused on thrombotic tendency and blood viscosity, providing new insight into mechanisms of the disease. Despite that knowledge about the mechanisms of development of CV disease in patients with OSAS is still incomplete, observations confirm a relationship between sleep-disordered breathing and the rheological properties (flow properties) of blood. While platelet dysfunction and hypercoagulability (PDMPs, PaI-1, and SF) play important roles in the pathogenesis of vascular disease, there are limited studies on the potential role of blood viscosity in the development of vascular disease in OSAS.
KeywordsObstructive sleep apnea syndrome Blood viscosity Hemostatic alterations Early atherosclerosis
The authors thank Miss Stephanie Grice MBiochem, MSc (Oxon), from the UK, for the editing of this manuscript.
Conflict of interest
The authors have no conflicts of interest or financial ties to disclose.
- 3.Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A et al (2008) Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 118:1080–1111PubMedCrossRefGoogle Scholar
- 8.Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ (2007) Handbook of Hemorheology and Hemodynamics. IOS, LansdaleGoogle Scholar
- 9.Holsworth RE, Wright JV (2012) Blood viscosity: the unifying parameter in cardiovascular disease risk. Holist Prim Ore 13:1Google Scholar
- 24.Zhang X, Yin K, Wang H, Su M, Yang Y (2003) Effect of continuous positive airway pressure treatment on elderly Chinese patients with obstructive sleep apnea in the prothrombotic state. Chin Med J (Engl) 116:1426–1428Google Scholar
- 40.von Kanel R, Loredo JS, Powell FL, Adler KA, Dimsdale JE (2005) Short-term isocapnic hypoxia and coagulation activation in patients with sleep apnea. Clin Hemorheol Microcirc 33:369–377Google Scholar
- 47.Jacobin-Valat MJ, Deramchia K, Mornet S, Hagemeyer CE, Bonetto S, Robert R, Biran M, Massot P, Miraux S, Sanchez S, Bouzier-Sore AK, Franconi JM, Duguet E, Clofent-Sanchez G (2010) MRI of inducible P-selectin expression in human activated platelets involved in the early stages of atherosclerosis. NMR Biomed 24:413–424PubMedGoogle Scholar
- 54.Haus E (1996) Biologic rhythms in hematology. Patol Biol (Paris) 44:618–630Google Scholar