Lung

, Volume 190, Issue 2, pp 183–188

Airway IFN-γ Production During RSV Bronchiolitis is Associated with Eosinophilic Inflammation

  • Chang Keun Kim
  • Zak Callaway
  • Young Yull Koh
  • Soo-Hee Kim
  • Takao Fujisawa
Article

Abstract

Study Objective

This study was designed to investigate the possible role of IFN-γ in eosinophil degranulation that occurs during respiratory syncytial virus (RSV) bronchiolitis.

Methods

Sixty-seven infants, 2–24 months old and hospitalized with their first episode of acute RSV bronchiolitis, were selected for this study. Eosinophil-active cytokine and chemokine profiles in nasal lavage supernatants taken within the first 48 h of admission were determined by a multiplex bead array system (Luminex). Comparisons were made with control (Control group) subjects (n = 20).

Results

Nasal IFN-γ levels were significantly higher (P < 0.0001) in RSV bronchiolitis (median = 4.4 pg/ml) infants compared to controls (0.0 pg/ml). IFN-γ levels correlated significantly with the levels of nasal eotaxin (r = 0.566, P < 0.0001), RANTES (r = 0.627, P < 0.0001), GM-CSF (r = 0.849, P < 0.0001), and EDN (r = 0.693, P < 0.001). Nasal interleukin (IL)-4, IL-5, and IL-13 were below sensitivity levels in most RSV bronchiolitis and control subjects.

Conclusion

These results suggest that IFN-γ may play an important role in eosinophilic inflammation in RSV bronchiolitis.

Keywords

Bronchiolitis Eosinophil Eosinophil-derived neurotoxin Interferon-γ Respiratory syncytial virus 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Chang Keun Kim
    • 1
  • Zak Callaway
    • 1
    • 2
  • Young Yull Koh
    • 3
  • Soo-Hee Kim
    • 1
  • Takao Fujisawa
    • 4
  1. 1.Department of Pediatrics, Asthma and Allergy CenterInje University Sanggye Paik HospitalSeoulKorea
  2. 2.School of Biological Sciences, College of Natural ScienceUniversity of UlsanUlsanKorea
  3. 3.Department of PediatricsSeoul National University HospitalSeoulKorea
  4. 4.Institute for Clinical ResearchMie National HospitalTsuJapan

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