, Volume 188, Supplement 1, pp 19–22

Nitric Oxide Measurement in Chronic Cough



Chronic cough is a common symptom-based diagnostic challenge for primary care physicians and respiratory specialists. Measurement of exhaled nitric oxide is a convenient, reproducible, and inexpensive point-of-service test. It can simplify the evaluation process of chronic cough by providing information regarding the state of airway inflammation. If exhaled nitric oxide is elevated, this is predictive of a favorable response to inhaled corticosteroids. This has the effect of reducing empirical trials for cough-variant asthma or eosinophilic bronchitis. The inclusion of exhaled nitric oxide in the diagnostic approach to chronic cough should be considered.


Chronic cough Quality of life Exhaled nitric oxide FeNO Cough-variant asthma Eosinophilic bronchitis 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Medicine, Division of Pulmonary and Critical CareMayo Clinic RochesterRochesterUSA

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