, Volume 185, Issue 5, pp 309–314 | Cite as

Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome

  • Ahmet UrsavasEmail author
  • Mehmet Karadag
  • Yesim Ozarda Ilcol
  • Ilker Ercan
  • Basak Burgazlioglu
  • Funda Coskun
  • R. Oktay Gozu


The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.


Insulin-like growth factor Obesity Sleep apnea 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Ahmet Ursavas
    • 1
    • 4
    Email author
  • Mehmet Karadag
    • 1
  • Yesim Ozarda Ilcol
    • 2
  • Ilker Ercan
    • 3
  • Basak Burgazlioglu
    • 1
  • Funda Coskun
    • 1
  • R. Oktay Gozu
    • 1
  1. 1.Department of Pulmonary MedicineSchool of Medicine, University of UludagBursaTurkey
  2. 2.Department of BiochemistrySchool of Medicine, University Of UludagBursaTurkey
  3. 3.Department of BiostatisticsSchool of Medicine, University Of UludagBursaTurkey
  4. 4.Uludağ Üniversitesi Tıp FakültesiBursaTurkey

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