Lung

, Volume 185, Issue 5, pp 295–301 | Cite as

Pulmonary Superinfection by Trichomonads in the Course of Acute Respiratory Distress Syndrome

  • Christophe Duboucher
  • Christophe Barbier
  • Alexandra Beltramini
  • Marianne Rona
  • Jean-Louis Ricome
  • Gérard Morel
  • Monique Capron
  • Raymond J. Pierce
  • Eduardo Dei-Cas
  • Eric Viscogliosi
Article

Abstract

The finding of trichomonads in bronchoalveolar lavage fluid (BALF) samples from an acute respiratory distress syndrome (ARDS) patient, never previously reported, incited us to search for these parasites retrospectively in the BALF of patients with ARDS or related pathologies. Eighty-four consecutive BALF samples have been reviewed. Results were compared with data from clinical files of patients included in this study. Detection and identification of trichomonads were based on cytologic characteristics. Subsequently, immunocytochemistry and in situ hybridization were performed in the last case of the series. Our results were as follows: (1) Trichomonads were detected in 25/84 BALFs (20/77 patients). Among the patients testing positive, 17 suffered from ARDS, about 30% of the ARDS patients included in the study. (2) Trichomonads were detected more frequently at a late ARDS stage. (3) No correlation was found between trichomonad detection and other data. (4) Within the group of trichomonad-infected ARDS patients, density of infection correlated with higher mortality. The late detection of these microorganisms in the course of ARDS suggested that trichomonad development is a secondary event. As BALFs obtained early in the course of ARDS were also included in the study, trichomonad incidence could be underestimated. The significance of trichomonad lung colonization in ARDS and its potential pathogenic role are unclear. Nevertheless, the question of an active role of trichomonads in the extension of alveolar lesions or in the limitation of recovery is clearly raised.

Keywords

Acute Respiratory Distress Syndrome Acute lung injury Trichomonas Parasitic lung disease Pneumocystis pneumonia 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Christophe Duboucher
    • 1
  • Christophe Barbier
    • 2
  • Alexandra Beltramini
    • 2
  • Marianne Rona
    • 1
  • Jean-Louis Ricome
    • 2
  • Gérard Morel
    • 3
  • Monique Capron
    • 4
  • Raymond J. Pierce
    • 4
  • Eduardo Dei-Cas
    • 5
  • Eric Viscogliosi
    • 4
  1. 1.Department of PathologyPoissy/Saint-Germain HospitalSaint-Germain-en-LayeFrance
  2. 2.Department of Intensive CarePoissy/Saint-Germain HospitalSaint-Germain-en-LayeFrance
  3. 3.The Unité Mixte CNRS-University Claude Bernard 5123VilleurbanneFrance
  4. 4.The Inserm U547, Lille Pasteur Institute & Lille 2 University Hospital Centre (EA3609)LilleFrance
  5. 5.Department of Ecology of ParasitismLille Pasteur Institute & Lille 2 University Hospital Centre (EA3609)LilleFrance

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