Smooth pursuit eye movements of patients with schizophrenia and affective disorder during clinical treatment

  • Klaus-Malte Flechtner
  • Bruno Steinacher
  • Robert Sauer
  • Arthur Mackert
ORIGINAL PAPER

DOI: 10.1007/s004060200011

Cite this article as:
Flechtner, KM., Steinacher, B., Sauer, R. et al. European Archives of Psychiatry and Clinical Neurosciences (2002) 252: 49. doi:10.1007/s004060200011

Abstract

Background Smooth pursuit eye movement dysfunctions are considered a biological indicator for vulnerability to schizophrenia. This study examines test-retest stability of specific eye movement variables such as velocity gain and different saccadic categories. Methods Smooth pursuit eye movements of 27 schizophrenic patients and 30 patients with major depression were examined three times during clinical treatment using high-resolution infrared oculography. Forty-one normal controls were retested after four weeks. Results Intraclass correlation coefficients as a measure for retest-stability were highly significant in each group for all time-points, except for anticipatory saccades in schizophrenics. No significant correlations were found between psychopathological status, neuroleptic medication and eye movement variables. Conclusions Our results indicate that the most important measures of eye tracking performance in psychiatric patients are not significantly influenced by neuroleptic medication or clinical state and are stable across time.

Key words smooth pursuit eye movement dysfunction eye tracking dysfunction eye movements schizophrenia affective disorder 

Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Klaus-Malte Flechtner
    • 1
  • Bruno Steinacher
    • 2
  • Robert Sauer
    • 2
  • Arthur Mackert
    • 3
  1. 1.Psychiatrische Klinik und Poliklinik der Freien Universität Berlin, Abteilung für SozialpsychiatrieDE
  2. 2.Psychiatrische Klinik und Poliklinik der Freien Universität Berlin, Abteilung für klinische Psychiatrie und PoliklinikDE
  3. 3.Psychiatrische Klinik und Poliklinik der Freien Universität Berlin, Kliniken im Theodor-Wenzel-Werk Neurologie und PsychiatrieDE
  4. 4.The Linden Centre, Woodlands Way, Broomfield, Chelmsford, Essex, CM1 7LF, UK, Tel.: +44-12 45/31 88 45, Fax: +44-12 45/31 88 01, E-Mail: Malte.Flechtner@nemhpt.nhs.ukGB

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