Advertisement

Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders

  • H. Hamakawa
  • Tadafumi Kato
  • J. Murashita
  • Nobumasa Kato
Original paper

Abstract

Proton magnetic resonance spectra were recorded from a subcortical region containing the basal ganglia in 40 patients with affective disorders (18 with bipolar disorder and 22 with major depression) and in 20 normal controls. The absolute concentration of the choline-containing compounds (Cho) in the patients with bipolar disorder in the depressive state was significantly higher than that in the normal controls. The patients with bipolar disorder had significantly higher levels of the Cho/creatine + phosphocreatine (Cr) and Cho/N-acetly-l-aspartate (NAA) peak ratio compared with the normal controls in both the depressive and euthymic states, with a tendency to higher levels in the depressive state. The Cho/NAA peak ratio was also significantly higher in the patients with major depression compared with the normal controls. These results suggest that the membrane phospholipid metabolism in the basal ganglia is altered in affective disorders.

Key words Mood disorder Magnetic resonance spectroscopy Basal ganglia Bipolar disorder Major depression Choline-containing compounds Brain imaging 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • H. Hamakawa
    • 1
  • Tadafumi Kato
    • 1
  • J. Murashita
    • 1
  • Nobumasa Kato
    • 1
  1. 1.Department of Psychiatry, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Shiga, 520-21, JapanJP

Personalised recommendations