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The resting-state functional connectivity of amygdala subregions associated with post-traumatic stress symptom and sleep quality in trauma survivors

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Abstract

Neuroimaging findings suggest that the amygdala plays a primary role in both the psychopathology of posttraumatic stress disorder (PTSD) and poor sleep quality, which are common in trauma survivors. However, the neural mechanisms of these two problems in trauma survivors associated with amygdala remain unclear. In the current study, we aimed to explore the role of functional connectivity of amygdala subregions in both PTSD symptoms and poor sleep quality. A total of 94 trauma-exposed subjects were scanned on a 3T MR system using resting-state functional magnetic resonance imaging. Both Pittsburgh Sleep Quality Index and Clinician-Administered PTSD Scale scores were negatively correlated with the resting-state functional connectivity between the left basolateral amygdala-left medial prefrontal cortex and the right basolateral amygdala-right medial prefrontal cortex. Our findings suggest a shared amygdala subregional neural circuitry underlying the neuropathological mechanisms of PTSD symptoms and poor sleep quality in trauma survivors.

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Acknowledgements

This work was funded by National Natural Science Foundation of China (Grant No. 81701328, 81871061, and 61973090); National Key Research & Development Program of China (Grant No. 2016YFC1307200); The Special Project on Natural Chronic Non-infectious Diseases (Grant No. 2016YFC1307201); Department of Science & Technology of Sichuan Province (Grant No. 2018 SZ0131); China Postdoctoral Science Foundation (Grant No. 2017M612972) and Postdoctoral Foundation of Sichuan University (Grant No. 2018SCU12042) to Dr. H.Z..

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Correspondence to Wei Zhang.

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Wang, Z., Zhu, H., Yuan, M. et al. The resting-state functional connectivity of amygdala subregions associated with post-traumatic stress symptom and sleep quality in trauma survivors. Eur Arch Psychiatry Clin Neurosci (2020). https://doi.org/10.1007/s00406-020-01104-3

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Keywords

  • Functional connectivity
  • Amygdala subregions
  • Trauma-exposed
  • PTSD
  • Sleep