Lack of dopamine D1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model
- 100 Downloads
It is reported that dopamine D1 receptors in the medial prefrontal cortex play a role in the antidepressant actions of (R,S)-ketamine. However, its role in the antidepressant actions of (R)-ketamine, which is more potent than (S)-ketamine, is unknown. In the locomotion test, tail suspension test, forced swimming test and 1% sucrose preference test, pretreatment with dopamine D1 receptor antagonist SCH-23390 did not block the antidepressant effects of (R)-ketamine in the susceptible mice after chronic social defeat stress. These findings suggest that dopamine D1 receptors may not play a major role in the antidepressant actions of (R)-ketamine.
KeywordsAntidepressant (R)-ketamine Dopamine D1 receptor Social defeat stress
This study was supported by AMED (to K.H., JP18dm0107119). Dr. Hashimoto is an inventor on a filed patent application on “The use of (R)-ketamine in the treatment of psychiatric diseases” by Chiba University. Dr. Hashimoto has received research support from Dainippon-Sumitomo, Otsuka, and Taisho.
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflict of interest.
- 2.Kishimoto T, Chawla JM, Hagi K, Zarate CA, Kane JM, Bauer M, Correll CU (2016) Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories. Psychol Med 46(7):1459–1472CrossRefGoogle Scholar
- 11.Zhang K, Ma M, Dong C, Hashimoto K (2018) Role of inflammatory bone markers in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model. Int J Neuropsychopharmacol 21(11):1025–1030Google Scholar
- 24.Ago Y, Tanabe W, Higuchi M, Tsukada S, Hashimoto K, Hashimoto H (2018) (R)-ketmaine, (S)-ketamine and their metabolites affect differentially in vivo monoamine release in the prefrontal cortex of mice: different involvement of AMPA receptor. Poster W-131 at 57th annual meeting of The American College of Neuropsychopharmacology, Hollywood, FL, 12 Dec 2018Google Scholar