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Lack of dopamine D1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model

  • Lijia Chang
  • Kai Zhang
  • Yaoyu Pu
  • Youge Qu
  • Si-ming Wang
  • Zhongwei Xiong
  • Yukihiko Shirayama
  • Kenji HashimotoEmail author
Short Communication
  • 100 Downloads

Abstract

It is reported that dopamine D1 receptors in the medial prefrontal cortex play a role in the antidepressant actions of (R,S)-ketamine. However, its role in the antidepressant actions of (R)-ketamine, which is more potent than (S)-ketamine, is unknown. In the locomotion test, tail suspension test, forced swimming test and 1% sucrose preference test, pretreatment with dopamine D1 receptor antagonist SCH-23390 did not block the antidepressant effects of (R)-ketamine in the susceptible mice after chronic social defeat stress. These findings suggest that dopamine D1 receptors may not play a major role in the antidepressant actions of (R)-ketamine.

Keywords

Antidepressant (R)-ketamine Dopamine D1 receptor Social defeat stress 

Notes

Acknowledgements

This study was supported by AMED (to K.H., JP18dm0107119). Dr. Hashimoto is an inventor on a filed patent application on “The use of (R)-ketamine in the treatment of psychiatric diseases” by Chiba University. Dr. Hashimoto has received research support from Dainippon-Sumitomo, Otsuka, and Taisho.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Lijia Chang
    • 1
  • Kai Zhang
    • 1
  • Yaoyu Pu
    • 1
  • Youge Qu
    • 1
  • Si-ming Wang
    • 1
  • Zhongwei Xiong
    • 1
  • Yukihiko Shirayama
    • 1
    • 2
  • Kenji Hashimoto
    • 1
    Email author
  1. 1.Division of Clinical NeuroscienceChiba University Center for Forensic Mental HealthChibaJapan
  2. 2.Department of PsychiatryTeikyo University Chiba Medical CenterIchiharaJapan

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