STX1A gene variations contribute to the susceptibility of children attention-deficit/hyperactivity disorder: a case–control association study

  • Min Wang
  • Xue Gu
  • Xin Huang
  • Qi Zhang
  • Xinzhen Chen
  • Jing WuEmail author
Original Paper


It was presumed syntaxin-1A (STX1A) might relate to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), but the results were inconsistent. The present study aims to confirm whether the STX1A gene is involved in the susceptibility of children ADHD. We genotyped three single nucleotide polymorphisms (SNPs) of STX1A gene using Sequenom MassARRAY technology. A case–control study was performed among Chinese Han population including 754 cases and 772 controls from two different provinces. The Conners Parent Symptom Questionnaire and Integrated Visual and Auditory Continuous Performance Test were used to assess ADHD clinical symptoms. We found for the first time that rs3793243 GG genotype carriers had a lower risk of ADHD compared with AA genotype (OR 0.564, 95% confidence interval (CI) 0.406–0.692, P = 0.001), and rs875342 was also associated with children ADHD (OR 1.806, 95% CI 1.349–2.591, P = 0.001). In addition, the two positive SNPs were also significantly associated with the clinical characteristics of ADHD. Expression quantitative trait loci analysis indicated that rs3793243 might mediate STX1A gene expression. Using a case–control study to explore the association between STX1A gene and children ADHD in Chinese Han population, our results suggest STX1A genetic variants might contribute to the susceptibility of children ADHD.


Attention-deficit/hyperactivity disorder STX1A gene Association study Genetic susceptibility 



We are sincerely grateful to Dr. Jun Lin from Wuhan Medical and Health Center for Women and Children, and Dr. Yan Zhong from Children's Hospital of Hunan province for their support to our study. This study was supported partially by the National Natural Science Foundation of China (81773456), and the Fundamental Research Funds for the Central Universities, HUST (2016 YXMS218) to Dr. Jing Wu.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interests.

Informed consent

Written informed consent was obtained from all participants. The Ethics Committees of Tongji Medical College of Huazhong University of Science and Technology approved this study.

Supplementary material

406_2019_1010_MOESM1_ESM.docx (14 kb)
Supplementary file1 (DOCX 14 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, School of Public HealthTongji Medical College, Huazhong University of Science and TechnologyWuhanPeople’s Republic of China
  2. 2.Department of Epidemiology and Biostatistics, School of Public HealthTongji Medical College, Huazhong University of Science and TechnologyWuhanPeople’s Republic of China

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