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Cerebrospinal fluid markers analysis in the differential diagnosis of dementia with Lewy bodies and Parkinson’s disease dementia

  • Karin Gmitterová
  • Joanna Gawinecka
  • Franc Llorens
  • Daniela Varges
  • Peter Valkovič
  • Inga Zerr
Original Paper

Abstract

Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) share a couple of clinical similarities that is often a source of diagnostic pitfalls. We evaluated the discriminatory potential of brain-derived CSF markers [tau, p-tau (181P), Aβ1−42, NSE and S100B] across the spectrum of Lewy body disorders and assessed whether particular markers are associated with cognitive status in investigated patients. The tau CSF level, amyloid β1−42 and p-tau/tau ratio were helpful in the distinction between DLB and PDD (p = 0.04, p = 0.002 and p = 0.02, respectively) as well as from PD patients (p < 0.001, p = 0.001 and p = 0.002, respectively). Furthermore, the p-tau/tau ratio enabled the differentiation of DLB with mild dementia from PDD patients (p = 0.02). The CSF tau and p-tau levels in DLB and CSF tau and p-tau/tau ratio in PDD patients reflected the severity of dementia. Rapid disease course was associated with the decrease of Aβ1−42 in DLB but not in PDD. Elevation of S100B in DLB (p < 0.0001) as well as in PDD patients (p = 0.002) in comparison to controls was estimated. Hence, with the appropriate clinical context; the CSF marker profile could be helpful in distinguishing DLB from PDD patients even in early stages of dementia.

Keywords

Parkinson’s disease dementia Lewy body dementia Cerebrospinal fluid Tau protein Neuron-specific enolase Protein S100B 

Notes

Acknowledgements

Special thanks to Barbara Ciesielczyk for the technical assistance. We would also like to thank Maja Schneider Dominco and Jolanthe Ehrlich for editorial assistance and Adrian Bronson for syntax correction.

Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest relevant to manuscript.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Neurology, Clinical Dementia Center and DZNE, National TSE Reference Centre, University Medical SchoolGeorg-August UniversityGöttingenGermany
  2. 2.Second Department of NeurologyComenius UniversityBratislavaSlovakia
  3. 3.Institute for Clinical ChemistryUniversity Hospital ZurichZurichSwitzerland

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