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Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity

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Abstract

Background

The study of cerebral underpinnings of schizophrenia may benefit from the high temporal resolution of electromagnetic techniques, but its spatial resolution is low. However, source imaging approaches such as low-resolution brain electromagnetic tomography (LORETA) allow for an acceptable compromise between spatial and temporal resolutions.

Methods

We combined LORETA with 32 channels and 3-Tesla diffusion magnetic resonance (Dmr) to study cerebral dysfunction in 38 schizophrenia patients (17 first episodes, FE), compared to 53 healthy controls. The EEG was acquired with subjects performing an odd-ball task. Analyses included an adaptive window of interest to take into account the interindividual variability of P300 latency. We compared source activation patters to distractor (P3a) and target (P3b) tones within- and between-groups.

Results

Patients showed a reduced activation in anterior cingulate and lateral and medial prefrontal cortices, as well as inferior/orbital frontal regions. This was also found in the FE patients alone. The activation was directly related to IQ in the patients and controls and to working memory performance in controls. Symptoms were unrelated to source activation. Fractional anisotropy in the tracts connecting lateral prefrontal and anterior cingulate regions predicted source activation in these regions in the patients.

Conclusions

These results replicate the source activation deficit found in a previous study with smaller sample size and a lower number of sensors and suggest an association between structural connectivity deficits and functional alterations.

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Acknowledgements

This study has been partially supported by the “Fondo de Investigaciones Sanitarias” from Instituto de Salud Carlos III (PI11/02708, PI11/02203 and PI15/00299), Consejería de Educación de Castilla y Leon VA057P17 and the Gerencia Regional de Salud de Castilla y León (GRS 1485/A/17 and GRS 1263/A/16) grants to V. Molina; Ministry of Economy and Competitiveness (MINECO), Spain, under contract DPI2017-83989-R and Fundación BBVA grants for researchers and cultural creators 2016; a predoctoral research fellowship from the Consejería de Educación—Junta de Castilla to A. Lubeiro and Grant TEC2013-44194-P from the Ministerio de Economía y Competitividad of Spain. CIBER-BBN is an initiative of the Instituto de Salud Carlos III, Spain.

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Authors and Affiliations

  1. Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain

    Vicente Molina & Alba Lubeiro

  2. Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain

    Vicente Molina, Rodrigo de Luis & Alba Lubeiro

  3. Psychiatry Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003, Valladolid, Spain

    Vicente Molina & Patricia Marqués

  4. Neurosciences Institute of Castilla y León (INCYL), Pintor Fernando Gallego, University of Salamanca, 1, 37007, Salamanca, Spain

    Vicente Molina, Jesús Poza & Roberto Hornero

  5. Automatic Control Department (ESAII), Biomedical Engineering Research Center (CREB), Polytechnic University of Catalonia, Barcelona, Spain

    Alejandro Bachiller, Joan Francesc Alonso, Miguel Angel Mañanas & Sergio Romero

  6. Biomedical Engineering Group, ETS Ingenieros de Telecomunicación, University of Paseo de Belén, 15, 47011, Valladolid, Spain

    Alejandro Bachiller, Jesús Poza & Roberto Hornero

  7. Instituto de Investigación en Matemática (IMUVA), University of Valladolid, Valladolid, Spain

    Jesús Poza & Roberto Hornero

  8. Imaging Processing Laboratory, University of Valladolid, Paseo de Belén, 15, 47011, Valladolid, Spain

    Rodrigo de Luis

  9. CIBER-BBN, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Madrid, Spain

    Joan Francesc Alonso, Miguel Angel Mañanas & Sergio Romero

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  1. Vicente Molina
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Correspondence to Vicente Molina.

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Molina, V., Bachiller, A., de Luis, R. et al. Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity. Eur Arch Psychiatry Clin Neurosci 269, 419–428 (2019). https://doi.org/10.1007/s00406-018-0877-3

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  • DOI: https://doi.org/10.1007/s00406-018-0877-3

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