Mindfulness-based cognitive therapy for depressed individuals improves suppression of irrelevant mental-sets
An impaired ability to suppress currently irrelevant mental-sets is a key cognitive deficit in depression. Mindfulness-based cognitive therapy (MBCT) was specifically designed to help depressed individuals avoid getting caught in such irrelevant mental-sets. In the current study, a group assigned to MBCT plus treatment-as-usual (n = 22) exhibited significantly lower depression scores and greater improvements in irrelevant mental-set suppression compared to a wait-list plus treatment-as-usual (n = 18) group. Improvements in mental-set-suppression were associated with improvements in depression scores. Results provide the first evidence that MBCT can improve suppression of irrelevant mental-sets and that such improvements are associated with depressive alleviation.
KeywordsMindfulness-based cognitive therapy Depression Mental-set Competitor rule suppression
Depression is a leading cause of disability and one of the most common mental disorders . It is characterized by impaired ability to suppress competing or currently irrelevant mental-sets [2, 3, 4, 5, 6, 7, 8], such as distracting ruminative thoughts. Impairments in mental-set suppression have been found to predict onset and recurrence of depression, correlate with depressive rumination [9, 10], and mediate symptom severity [4, 11]. However, little is known about whether or how suppression impairments can be improved and if this would affect depressive symptomatology. This study aims to determine whether mindfulness training can improve mental-set suppression and whether such improvement is associated with depressive alleviation.
Mindfulness-based cognitive therapy (MBCT) specifically targets avoiding getting caught in ruminative mental-sets [12, 13, 14] and can prevent depressive relapse [13, 15]. While mindfulness training can improve cognitive functioning  including mental-set suppression [17, 18, 19] primarily among healthy adults, cognition improvements among depressed individuals remain largely unexplored.
The current study focuses on Competitor Rule Suppression CRS  as a measure of mental-set suppression. CRS refers to suppression of mental-sets which implicate a response that competes with the correct or currently relevant response (for example, suppressing self-critical thoughts of giving up rather than staying focused on a difficult task). CRS specifically counters “troublemaking” irrelevant mental-sets by tagging them in episodic memory as “to-be-suppressed” , thus facilitating adherence to current task demands. CRS is measured within a task-switching paradigm [22, 23], in which the context and task requirements are in constant flux. This design permits examination of dynamic fine-tuning of suppression processes [20, 24, 25], rather than more crude and consistent suppression of a single process or stimulus seen in other suppression measures such as the Stroop [20, 26]. We hypothesized that MBCT will improve CRS and that such improvements will be linked to depressive symptom reduction.
Baseline demographic and clinical characteristics of participants (all baseline group differences are nonsignificant; minimal p = 0.49)
MBCT + TAU
Wait-list + TAU
Meeting major depressive disorder criteria (%)
Comorbid anxiety disorder (%)
Mindfulness-based cognitive therapy program
The 8-week MBCT program was led by two MBCT teachers with 8–13 years experience of teaching mindfulness-based group programs and blind to the study’s hypotheses. The program followed the guidelines of Segal, Williams, and Teasdale .
The Mini International Neuropsychiatric Interview  version 5.0.0 and the HAM-D-28; [27, 29] were administered by trained and certified psychiatrists and psychologists from Mass. General Hospital to assess inclusion criteria. The Beck Depression Inventory-II (BDI-II ) was administered 0–2 weeks prior to the MBCT program and every 2–3 weeks during the program to measure changes in depressive symptoms. The Rumination Response Scale was also administered. These data are detailed in the electronic supplementary material.
Competitor rule suppression
Participants completed a phone screen, then signed the consent form, and underwent the MINI and the clinician-rated HAM-D-28 to assess eligibility. They then completed the CRS task, the BDI-II, and other measures outside the scope of this report. Testing procedures were repeated for all participants 0–3 weeks after the MBCT program. Clinical assessors were blind to group allocation.
Groups had statistically equivalent baseline HAM-D-28 scores, both when examining all participants t(35) = 0.47, ns (Table 1) and when examining only participants with post-program data (t(23) = 0.71, ns). ANCOVA conducted on post-program HAM-D-28 scores while controlling for baseline scores revealed a significant effect for group, with MBCT + TAU (M = 12.63, SD = 8.76) exhibiting lower HAM-D-28 scores post-program than wait-list + TAU (M = 20.44, SD = 6.35), F(1,22) = 4.77, p < 0.05, ηp2 = 0.178, 90% CI (0.005, 0.39; Fig. 3).
The relationship between CRS and depressive symptoms
Multiple regression was used to predict change in BDI-II based on change in CRS error rates and RT. A significant regression model was found (F(1,19) = 6.91, p = 0.02) with change in error rates associated with change in depressive symptoms. The multiple correlation coefficient was 0.52, indicating that overall improvement in irrelevant mental-set suppression explained 26.7% of the variance in BDI-II scores (β = 0.52, p = 0.02; R2 = 0.267). A similar regression was calculated with group as an additional factor. A significant model was found (F(2,18) = 19.20, p < 0.001), with a multiple correlation coefficient of 0.82 (R2 = 0.64). Group (β = 0.68, p < 0.001) was a significant factor and error rates just attained significance (β = 0.30, p = 0.05).
This study found significantly lower depression scores and significantly higher CRS following MBCT compared to wait-list + TAU. Moreover, improvements in CRS were significantly associated with improvements in BDI-II scores. These results constitute the first empirical evidence indicating MBCT can help improve mental-set suppression, as well as the first evidence linking such improvements to depressive alleviation.
CRS has been labeled “smart inhibition”  since it measures the ability to detect and target only conflicting and “troublemaking” mental-sets. CRS operates on a higher order and abstract level than most inhibition measures in the sense that it does not merely involve suppression a competing response but of a competing rule, regardless of the specific response [20, 21]. This type of finely tuned suppression mechanism fits particularly well with the mindfulness training practiced in MBCT, which focuses on avoiding getting caught in depression-related thoughts that often conflict with one’s ability to focus on current task demands. Our findings suggest that reductions in depressive symptoms are associated with such specialized and specific suppression. These benefits following improved specific suppression contrast with broad and more general thought suppression among depressed individuals, which may prolong or worsen depressive symptoms [34, 35].
The primary limitation of this study was the small sample. Possibly some null effects would have reached significance in a larger sample. The small sample is somewhat less problematic with regard to the significant differences found in this study, since the more probable statistical error in this case is of type I. Second, the use of a wait-list rather than an active control program limits us to only attribute findings to the MBCT program as a whole, rather than to mindfulness training specifically. Finally, although group assignment for most participants was random, the first few participants were quasi-randomized by enrollment order.
Although the current results should be confirmed in larger samples, they provide preliminary evidence that MBCT can improve mental-set suppression, a key cognitive deficit in depression. Furthermore, these findings demonstrate that these improvements in are associated with improvements in depressive symptoms.
Authors wish to thankfully acknowledge Dr. Gaelle Desbordes, Prof. Nachshon Meiran, Dr. Javeria Ali Hashmi, Ms. Kathryn Meade, and Ms. Ana Acevedo-Barga for their contributions to this work. This work was funded by a research grant to the first author from the AlterMed Research Foundation.
Compliance with ethical standards
Conflict of interest
Authors declare no conflict of interest.
|Funder Name||Grant Number||Funding Note|
|Altermed Research Foundation|
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