Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin
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The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 −/−) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT−/−) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 −/− mice, whereas no significant changes were observed in SERT−/− mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 −/− but not of SERT−/− mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.
KeywordsBDNF SERT TPH2 Serotonin Depression Antidepressant
This work was supported by the Bundesministerium für Bildung und Forschung (Center for Stroke Research Berlin to K.G. and G.K.) and DFG Grant KL 2805/1-1 to F.K. We would like to thank Thorsten Riepenhausen, Silvia Saft, and Sabine Grueger for excellent technical support.
Conflict of interest