Retinal dysfunction of contrast processing in major depression also apparent in cortical activity
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Depressive disorder is often associated with the subjective experience of altered visual perception. Recent research has produced growing evidence for involvement of the visual system in the pathophysiology of depressive disorder. Using the pattern electroretinogram (PERG), we found reduced retinal contrast response in patients with major depression. Based on this observation, the question arises whether this change has a cortical correlate. To evaluate this, we analyzed the visual evoked potential (VEP) of the occipital cortex in 40 patients with depressive disorder and 28 healthy controls. As visual stimuli, checkerboard stimuli of 0.51° check size, 12.5 reversals per second and a contrast of 3–80 % was used. In addition to the PERG, we recorded the VEP with an Oz versus FPz derivation. The amplitude versus contrast transfer function was compared across the two groups and correlated with the severity of depression, as measured by the Hamilton Depression Rating Scale and the Beck Depression Inventory. Patients with major depression displayed significantly reduced VEP amplitudes at all contrast levels compared to control subjects (p = 0.029). The VEP amplitude correlated with psychometric measures for severity of depression. The degree of depression reduced the contrast transfer function in the VEP to a lesser extent than in the PERG: While the PERG is reduced to ≈50 %, the VEP is reduced to 75 %. Our results suggest that depression affects the cortical response in major depression, but less so than the retinal responses. Modified contrast adaptation in the lateral geniculate nucleus or cortex possibly moderates the increased losses in the retina.
KeywordsMajor depression Contrast sensitivity Dopamine Visual evoked potentials
Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
- 1.WHO (2004) WHO | The global burden of disease: 2004 update. In: WHO. http://www.who.int/healthinfo/global_burden_disease/2004_report_update/en/. Accessed 13 Nov 2013
- 4.American Psychiatric Association (2000) Diagnostic statistical manual of mental disorders: DSM-IV-TR, Revised. American Psychiatric Association, Washington, DCGoogle Scholar
- 27.Bach M (2000) Freiburg evoked potentials. http://www.michaelbach.de/ep2000.html
- 32.WaveMetrics (2014) WaveMetrics—scientific graphing, data analysis, curve fitting and image processing software. http://www.wavemetrics.com/index.html. Accessed 11 Nov 2014
- 33.R Development Core Team (2014) R: A language and environment for statistical computing. http://www.R-project.org. Accessed 18 Aug 2014
- 38.Heinrich TS, Bach M (2001) Contrast adaptation in human retina and cortex. IOVS 42:2721–2727Google Scholar