Body fat distribution and associations with metabolic and clinical characteristics in bipolar individuals

  • Nina Lackner
  • Harald Mangge
  • Eva Z. ReininghausEmail author
  • Roger S. McIntyre
  • Susanne A. Bengesser
  • Armin Birner
  • Bernd Reininghaus
  • Hans-Peter Kapfhammer
  • Sandra J. Wallner-Liebmann
Original Paper


Overweight and obesity differentially affect bipolar disorder (BD) and are associated with a poorer prognosis. Herein, we sought to evaluate body fat distribution in a well-characterized BD sample. Anthropometric measures (i.e., body mass index, waist-to-hip ratio, waist-to-height ratio, waist circumference, hip circumference, and lipometry) of 100 BD individuals were compared with data of 57 matched mentally healthy controls. Additionally, fasting serum parameters including metabolic parameters and monoamines were analyzed. Findings indicate that similar to US BD cohorts, Austrian patients exhibit an increased central body fat accumulation (i.e., higher subcutaneous adipose tissue at upper abdomen) accompanying with the harmful IDF-defined metabolic syndrome. In addition, positive associations between epinephrine as well as staging and fat parameters were detected.


Bipolar disorder Subcutaneous adipose tissue thickness Body composition Central obesity Metabolic syndrome Staging 


Conflict of interest

The authors have no conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Nina Lackner
    • 1
  • Harald Mangge
    • 2
  • Eva Z. Reininghaus
    • 1
    Email author
  • Roger S. McIntyre
    • 3
  • Susanne A. Bengesser
    • 1
  • Armin Birner
    • 1
  • Bernd Reininghaus
    • 1
  • Hans-Peter Kapfhammer
    • 1
  • Sandra J. Wallner-Liebmann
    • 4
  1. 1.Department of PsychiatryUniversity Clinic for Psychiatry, Medical University GrazGrazAustria
  2. 2.Research Unit on Lifestyle and Inflammation-associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory DiagnosticsMedical University GrazGrazAustria
  3. 3.Mood Disorders Psychopharmacology UnitUniversity Health NetworkTorontoCanada
  4. 4.Department of Pathophysiology and ImmunologyMedical University GrazGrazAustria

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