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Body fat distribution and associations with metabolic and clinical characteristics in bipolar individuals

  • Nina Lackner
  • Harald Mangge
  • Eva Z. ReininghausEmail author
  • Roger S. McIntyre
  • Susanne A. Bengesser
  • Armin Birner
  • Bernd Reininghaus
  • Hans-Peter Kapfhammer
  • Sandra J. Wallner-Liebmann
Original Paper

Abstract

Overweight and obesity differentially affect bipolar disorder (BD) and are associated with a poorer prognosis. Herein, we sought to evaluate body fat distribution in a well-characterized BD sample. Anthropometric measures (i.e., body mass index, waist-to-hip ratio, waist-to-height ratio, waist circumference, hip circumference, and lipometry) of 100 BD individuals were compared with data of 57 matched mentally healthy controls. Additionally, fasting serum parameters including metabolic parameters and monoamines were analyzed. Findings indicate that similar to US BD cohorts, Austrian patients exhibit an increased central body fat accumulation (i.e., higher subcutaneous adipose tissue at upper abdomen) accompanying with the harmful IDF-defined metabolic syndrome. In addition, positive associations between epinephrine as well as staging and fat parameters were detected.

Keywords

Bipolar disorder Subcutaneous adipose tissue thickness Body composition Central obesity Metabolic syndrome Staging 

Notes

Conflict of interest

The authors have no conflicts of interest.

References

  1. 1.
    McIntyre RS, Konarski JZ, Wilkins K, Soczynska JK, Kennedy SH (2008) Obesity in bipolar disorder and major depressive disorder: results from a national community health survey on mental health and well-being. Can J Psychiatry 51:274–280Google Scholar
  2. 2.
    Chauvet-Gélinier JC, Gaubil I, Kaladjian A, Bonin B (2012) Bipolar disorders and somatic comorbidities: a focus on metabolic syndrome, diabetes and cardiovascular disease. L’Encephale 38:167–172CrossRefGoogle Scholar
  3. 3.
    Czepielewski L, Daruy Filho L, Brietzke E, Grassi-Oliveira R (2013) Bipolar disorder and metabolic syndrome: a systematic review. Rev Bras Psiquiatr 35:88–93CrossRefPubMedGoogle Scholar
  4. 4.
    Fagiolini A, Chengappa KN, Soreca I, Chang J (2008) Bipolar disorder and the metabolic syndrome: causal factors, psychiatric outcomes and economic burden. CNS drugs 22:655–669CrossRefPubMedGoogle Scholar
  5. 5.
    Hung CI, Liu CY, Hsiao MC, Yu NW, Chu CL (2014) Metabolic syndrome among psychiatric outpatients with mood and anxiety disorders. BMC psychiatry 14:185CrossRefPubMedCentralPubMedGoogle Scholar
  6. 6.
    McElroy SL, Keck PE Jr (2014) Metabolic syndrome in bipolar disorder: a review with a focus on bipolar depression. J Clin Psychiatry 75:46–61CrossRefPubMedGoogle Scholar
  7. 7.
    McIntyre RS, Woldeyohannes HO, Soczynska JK, Miranda A, Lachowski A, Liauw SS, Kennedy SH (2010) The rate of metabolic syndrome in euthymic Canadian individuals with bipolar I/II disorder. Adv Ther 27:828–836CrossRefPubMedGoogle Scholar
  8. 8.
    Sicras A, Rejas J, Navarro R, Serrat J, Blanca M (2008) Metabolic syndrome in bipolar disorder: a cross-sectional assessment of a health management organization database. Bipolar Disord 10:607–616CrossRefPubMedGoogle Scholar
  9. 9.
    Ruetsch O, Viala A, Bardou H, Martin P, Vacheron MN (2005) Psychotropic drugs induced weight gain: a review of the literature concerning epidemiological data, mechanisms and management. Encephale 31:507–516CrossRefPubMedGoogle Scholar
  10. 10.
    Maina G, Salvi V, Vitalucci A, D’Ambrosio V, Bogetto F (2008) Prevalence and correlates of overweight in drug-naive individuals with bipolar disorder. J Affect Disord 110:149–155CrossRefPubMedGoogle Scholar
  11. 11.
    McElroy SL, Kotwal R, Malhotra S, Nelson EB, Keck PE, Nemeroff CB (2004) Are mood disorders and obesity related? a review for the mental health professional. J Clin Psychiatry 65:634–651CrossRefPubMedGoogle Scholar
  12. 12.
    Fagiolini A, Kupfer DJ, Houck PR, Novick DM, Frank E (2003) Obesity as a correlate of outcome in individuals with bipolar I disorder. Am J Psychiatry 160:112–117CrossRefPubMedGoogle Scholar
  13. 13.
    Calkin C, Van de Velde C, Růžičková M, Slaney C, Garnham J, Hajek T, Alda M (2009) Can body mass index help predict outcome in individuals with bipolar disorder? Bipolar Disord 11:650–656CrossRefPubMedCentralPubMedGoogle Scholar
  14. 14.
    Goldstein BI, Liu SM, Zivkovic N, Schaffer A, Chien LC, Blanco C (2011) The burden of obesity among adults with bipolar disorder in the United States. Bipolar Disord 13:387–395CrossRefPubMedCentralPubMedGoogle Scholar
  15. 15.
    Yim CY, Soczynska JK, Kennedy SH, Woldeyohannes HO, Brietzke E, McIntyre RS (2011) The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder. Eur Psychiatry 27:223–228CrossRefPubMedGoogle Scholar
  16. 16.
    Ludescher B, Machann J, Eschweiler GW, Thamer C, Maenz C, Hipp A, et al (2011) Active depression is associated with regional adiposity in the upper abdomen and the neck. Int J Psychiatry Med 41:271–280CrossRefPubMedGoogle Scholar
  17. 17.
    Möller R, Tafeit E, Pieber TR, Sudi K, Reibnegger G (2000) Measurement of subcutaneous adipose tissue topography (SAT-Top) by means of a new optical device, LIPOMETER, and the evaluation of standard factor coefficients in healthy subjects. Am J Hum Biol 12:231–239CrossRefPubMedGoogle Scholar
  18. 18.
    Kapczinski F, Dias VV, Kauer-Sant’Anna M, Frey BN, Grassi-Oliveira R, Colom F, Berk M (2009) Clinical implications of a staging model for bipolar disorders. Expert Rev Neurother 9:957–966CrossRefPubMedGoogle Scholar
  19. 19.
    Zimmet P, Alberti KGMM, Serrano Ríos M (2005) A new International Diabetes Federation (IDF) worldwide definition of the metabolic syndrome: the rationale and the results. Rev Esp Cardiol (English Edition) 58:1371–1375Google Scholar
  20. 20.
    Rieder A, Rathmanner T, Kiefer I, Dorner T, Kunze M (2004) Österreichischer Diabetesbericht 2004: Daten, Fakten, Strategien. Bundesministerium für Gesundheit und Frauen, WienGoogle Scholar
  21. 21.
    Ibrahim MM (2010) Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev 11:11–18CrossRefPubMedGoogle Scholar
  22. 22.
    Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, O’Donnell CJ (2007) Abdominal visceral and subcutaneous adipose tissue compartments association with metabolic risk factors in the Framingham Heart Study. Circulation 116:39–48CrossRefPubMedGoogle Scholar
  23. 23.
    Mangge H, Almer G, Truschnig-Wilders M, Schmidt A, Gasser R, Fuchs D (2010) Inflammation, adiponectin, obesity and cardiovascular risk. Curr Med Chem 17:4511–4520CrossRefPubMedGoogle Scholar
  24. 24.
    Mangge H, Summers KL, Meinitzer A, Zelzer S, Almer G, Prassl R et al (2014) Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome. Obesity 22:195–201Google Scholar
  25. 25.
    Tsigos C, Chrousos GP (2003) Hypothalamic–pituitary–adrenal axis, neuroendocrine factors and stress. J Psychosom Res 53:865–871CrossRefGoogle Scholar
  26. 26.
    Berrettini WH, Nurnberger JI Jr, Scheinin M, Seppala T, Linnoila M, Narrow W, Simmons-Alling S, Gershon ES (1985) Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients. Biol Psychiatry 20:257–269CrossRefPubMedGoogle Scholar
  27. 27.
    Mansur RB, Cha DS, Asevedo E, McIntyre RS, Brietzke E (2013) Selfish brain and neuroprogression in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 43:66–71Google Scholar
  28. 28.
    Peters A, Schweiger U, Pellerin L, Hubold C, Oltmanns KM, Conrad M, Schultes B, Born J, Fehm HL (2004) The selfish brain: competition for energy resources. Neurosci Biobehav Rev 28:143–180CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Nina Lackner
    • 1
  • Harald Mangge
    • 2
  • Eva Z. Reininghaus
    • 1
    Email author
  • Roger S. McIntyre
    • 3
  • Susanne A. Bengesser
    • 1
  • Armin Birner
    • 1
  • Bernd Reininghaus
    • 1
  • Hans-Peter Kapfhammer
    • 1
  • Sandra J. Wallner-Liebmann
    • 4
  1. 1.Department of PsychiatryUniversity Clinic for Psychiatry, Medical University GrazGrazAustria
  2. 2.Research Unit on Lifestyle and Inflammation-associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory DiagnosticsMedical University GrazGrazAustria
  3. 3.Mood Disorders Psychopharmacology UnitUniversity Health NetworkTorontoCanada
  4. 4.Department of Pathophysiology and ImmunologyMedical University GrazGrazAustria

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