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T. Kishi and N. Iwata: Varenicline for smoking cessation in people with schizophrenia: systematic review meta-analysis

  • A. Eden EvinsEmail author
  • L. Elliot Hong
  • Deanna L. Kelly
Letter to the Editor

Dear Prof. Dr. Falkai,

The meta-analysis of efficacy of varenicline for smoking cessation in schizophrenia by Kishi and Iwata published in European Archives of Psychiatry and Clinical Neuroscience inappropriately included two trials which were not smoking cessation trials, conducted in patients with schizophrenia with no intention to quit smoking, which caused the authors to erroneously conclude that varenicline is ineffective for smoking cessation in this important population of smokers [1]. The meta-analysis appropriately included the two randomized, controlled smoking cessation trials in smokers with schizophrenia that demonstrate efficacy for varenicline when added to behavioral smoking cessation support in this population at the end of the treatment [2, 3], but inappropriately included two randomized, controlled trials of varenicline as a putative cognitive enhancing agent in smokers and non-smokers with schizophrenia, who expressed no desire to quit smoking prior to enrollment,...

Keywords

Schizophrenia Smoking Cessation Psychotic Disorder Varenicline Smoking Cessation Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Dr. Evins is supported by NIH Grants R01 DA021245 Smoking Cessation and Smoking Relapse Prevention in Patients with Schizophrenia and K24 DA030443 Mentoring in Addiction Treatment Research.

Conflict of interest

Dr. Evins reports receiving study product and unrestricted research funding support to her institution from EnVivo Pharmaceuticals, GSK and Pfizer. Pfizer is the manufacturer of varenicline. Dr. Hong has received unrestricted research funding from Mitsubishi, Your Energy Systems LLC, and Pfizer. Pfizer is the manufacturer of varenicline. Dr. Kelly reports no potential conflicts.

References

  1. 1.
    Kishi T, Iwata N (2014) Varenicline for smoking cessation in people with schizophrenia: systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci. doi: 10.1007/s00406-014-0551-3
  2. 2.
    Williams JM, Anthenelli RM, Morris CD, Treadow J, Thompson JR, Yunis C, George TP (2012) A randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of varenicline for smoking cessation in patients with schizophrenia or schizoaffective disorder. J Clin Psychiatry 73(5):654–660CrossRefPubMedGoogle Scholar
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    Weiner E, Buchholz A, Coffay A, Liu F, McMahon RP, Buchanan RW, Kelly DL (2011) Varenicline for smoking cessation in people with schizophrenia: a double blind randomized pilot study. Schizophr Res 129(1):94–95CrossRefPubMedCentralPubMedGoogle Scholar
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    Callaghan RC, Veldhuizen S, Jeysingh T, Orlan C, Graham C, Kakouris G, Remington G, Gatley J (2014) Patterns of tobacco-related mortality among individuals diagnosed with schizophrenia, bipolar disorder, or depression. J Psychiatr Res 48(1):102–110CrossRefPubMedGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • A. Eden Evins
    • 1
    Email author
  • L. Elliot Hong
    • 2
  • Deanna L. Kelly
    • 2
  1. 1.Massachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.University of Maryland School of MedicineBaltimoreUSA

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