The impact of Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk—a European multicentre study on treatment-resistant major depressive disorder

  • Peter Höfer
  • Alexandra Schosser
  • Raffaella Calati
  • Alessandro Serretti
  • Isabelle Massat
  • Neslihan Aygun Kocabas
  • Anastasios Konstantinidis
  • Sylvie Linotte
  • Julien Mendlewicz
  • Daniel Souery
  • Joseph Zohar
  • Alzbeta Juven-Wetzler
  • Stuart Montgomery
  • Siegfried Kasper
Original Paper

DOI: 10.1007/s00406-012-0375-y

Cite this article as:
Höfer, P., Schosser, A., Calati, R. et al. Eur Arch Psychiatry Clin Neurosci (2013) 263: 385. doi:10.1007/s00406-012-0375-y

Abstract

Recently published data have reported associations between cytochrome P450 metabolizer status and suicidality. The aim of our study was to investigate the role of genetic polymorphisms of the cytochrome P450 genes on suicide risk and/or a personal history of suicide attempts. Two hundred forty-three major depressive disorder patients were collected in the context of a European multicentre resistant depression study and treated with antidepressants at adequate doses for at least 4 weeks. Suicidality was assessed using the Mini International Neuropsychiatric Interview and the Hamilton Rating Scale for Depression (HAM-D). Treatment response was defined as HAM-D ≤ 17 and remission as HAM-D ≤ 7 after 4 weeks of treatment with antidepressants at adequate dose. Genotyping was performed for all relevant variations of the CYP1A2 gene (*1A, *1F, *1C, *1 J, *1 K), the CYP2C9 gene (*2, *3), the CYP2C19 gene (*2, *17) and the CYP2D6 gene (*3, *4, *5, *6, *9, *19, *XN). No association between both suicide risk and personal history of suicide attempts, and the above mentioned metabolic profiles were found after multiple testing corrections. In conclusion, the investigated cytochrome gene polymorphisms do not seem to be associated with suicide risk and/or a personal history of suicide attempts, though methodological and sample size limitations do not allow definitive conclusions.

Keywords

CYP1A2 CYP2C9 CYP2C19 CYP2D6 Cytochrome genes Suicidality Pharmocogenetics 

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Peter Höfer
    • 1
  • Alexandra Schosser
    • 1
  • Raffaella Calati
    • 2
  • Alessandro Serretti
    • 2
  • Isabelle Massat
    • 3
  • Neslihan Aygun Kocabas
    • 3
    • 4
  • Anastasios Konstantinidis
    • 1
  • Sylvie Linotte
    • 5
  • Julien Mendlewicz
    • 5
  • Daniel Souery
    • 6
  • Joseph Zohar
    • 7
  • Alzbeta Juven-Wetzler
    • 7
  • Stuart Montgomery
    • 8
  • Siegfried Kasper
    • 1
  1. 1.Department of Psychiatry and PsychotherapyMedical University of ViennaViennaAustria
  2. 2.Institute of PsychiatryUniversity of BolognaBolognaItaly
  3. 3.Service de Psychopathologie de l’Enfant et de l’AdolescentHôpital Robert DebréParisFrance
  4. 4.Department of Toxicology, Faculty of PharmacyUniversity of GaziEtiler AnkaraTurkey
  5. 5.Université Libre de BruxellesBruxellesBelgium
  6. 6.Laboratoire de Psychologie Medicale, Centre Europe en de Psychologie MedicaleUniversité Libre de Bruxelles and Psy PlurielBruxellesBelgium
  7. 7.Chaim Sheba Medical CenterTel-HashomerIsrael
  8. 8.Imperial College, School of Medicine University of LondonLondonUK

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