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Chemokines in bipolar disorder: Trait or state?

  • Izabela Guimarães Barbosa
  • Natália Pessoa Rocha
  • Moisés Evandro Bauer
  • Aline Silva de Miranda
  • Rodrigo Barreto Huguet
  • Helton José Reis
  • Patricia A. Zunszain
  • Mark A. Horowitz
  • Carmine M. Pariante
  • Antônio Lúcio TeixeiraEmail author
Original Paper

Abstract

Recent evidence has suggested that inflammatory and immune mechanisms may play a role in the pathophysiology of bipolar disorder (BD). Only a few studies have assessed the profile of chemokines, a family of chemotactic cytokines related to the recruitment of leukocytes, in BD. The objective of our study was to evaluate the plasma levels of chemokines in BD patients in different mood states in comparison with healthy controls. Seventy BD type I patients (35 in euthymia and 35 in mania), and 50 healthy controls matched by age, gender, and education level were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatry Interview and the patients by the Young Mania Rating Scale and the Hamilton Depression Rating Scale. The plasma levels of CCL2, CCL3, CCL11, CCL24, CXCL8, and CXCL10 were measured by enzyme-linked immunosorbent assay. BD patients presented higher plasma levels of CCL11 (1.69-fold increase; p < 0.001), CCL24 (1.40-fold increase; p = 0.02), CXCL10 (1.45-fold increase; p < 0.001) and decreased plasma levels of CXCL8 (8.68-fold decrease p < 0.001). Logistic regression stressed the main effect of increased plasma levels of CXCL10 (OR = 1.009, 95 % CI = 1.000–1.018, p = 0.042) and CCL11 (OR = 1.002, 95 % CI = 1.001–1.003, p = 0.003) and decreased plasma levels of CXCL8 (OR = 0.995, 95 % CI = 0.990–0.999, p = 0.013) to BD. This study reinforces the view that BD is associated with an immune dysfunction.

Keywords

Bipolar disorder Chemokines Immunology Inflammation Mania 

Notes

Acknowledgments

This work was funded by the Brazilian funding agencies Fapemig and CNPq. Dr. Barbosa was the recipient of a CAPES scholarship during her sandwich doctorate in the Institute of Psychiatry, London.

Conflict of interest

None.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Izabela Guimarães Barbosa
    • 1
    • 2
  • Natália Pessoa Rocha
    • 2
  • Moisés Evandro Bauer
    • 3
  • Aline Silva de Miranda
    • 2
  • Rodrigo Barreto Huguet
    • 1
  • Helton José Reis
    • 1
  • Patricia A. Zunszain
    • 4
  • Mark A. Horowitz
    • 4
  • Carmine M. Pariante
    • 4
  • Antônio Lúcio Teixeira
    • 1
    • 2
    • 5
    Email author
  1. 1.Programa de Pós-Graduação em NeurociênciasUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Laboratório de Imunofarmacologia, Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  3. 3.Laboratório de Imunologia do Envelhecimento, Instituto de Pesquisas BiomédicasPontifícia Católica Universidade do Rio Grande do SulPorto AlegreBrazil
  4. 4.Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology (SPI-lab), Department of Psychological Medicine, Institute of PsychiatryKing’s College LondonLondonUK
  5. 5.Departamento de Clínica Médica da Faculdade de Medicina da UFMGBelo HorizonteBrazil

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