A comparison of adolescent- and adult-onset first-episode, non-affective psychosis: 2-year follow-up
- 395 Downloads
This study aimed to compare 2-year outcome among individuals with early-onset (EO; <18 years) versus adult-onset (AO) first-episode, non-affective psychosis. We compared clinical and treatment characteristics of 43 EO and 189 AO patients 2 years after their inclusion in a clinical epidemiologic population-based cohort study of first-episode psychosis. Outcome variables included symptom severity, remission status, drug abuse, treatment utilization, cognition and social functioning. At baseline, EO patients were more symptomatically compromised. However, these initial baseline differences were no longer significant at the 2-year follow-up. This study challenges the findings of a larger and older literature base consisting primarily of non-comparative studies concluding that teenage onset indicates a poor outcome. Our results indicate that adolescent-onset and adult-onset psychosis have similar prognostic trajectories, although both may predict a qualitatively different course from childhood-onset psychosis.
KeywordsFirst-episode psychosis Duration of untreated psychosis Adolescence Early-onset psychosis
- 3.Werry JS, McClellan JM (2001) Practice parameter for the assessment and treatment of children and adolescents with schizophrenia. J Am Acad Child Adolesc Psychiatry 40(7 suppl): 4S–23SGoogle Scholar
- 10.Zabala A, Rapado M, Arango C, Robles O, de la Serna E, Gonzalez C, Rodriguez-Sanchez JM, Andres P, Mayoral M, Bombin I (2010) Neuropsychological functioning in early-onset first-episode psychosis: comparison of diagnostic subgroups. Eur Arch Psychiatry Clin Neurosci 260(3):225–233PubMedCrossRefGoogle Scholar
- 15.American Psychiatric Assosiation (2005) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Assosiation, Washington, DCGoogle Scholar
- 23.Friis S, Larsen TK, Melle I, Opjordsmoen S, Johannessen JO, Haahr U, Simonsen E, Rund BR, Vaglum P, McGlashan T (2003) Methodological pitfalls in early detection studies—the NAPE Lecture 2002. Nordic Association for Psychiatric Epidemiology. Acta Psychiatr Scand 107(1):3–9PubMedCrossRefGoogle Scholar