A comparison of adolescent- and adult-onset first-episode, non-affective psychosis: 2-year follow-up

  • Johannes Langeveld
  • Inge Joa
  • Svein Friis
  • Wenche ten Velden Hegelstad
  • Ingrid Melle
  • Jan O. Johannessen
  • Stein Opjordsmoen
  • Erik Simonsen
  • Per Vaglum
  • Bjørn Auestad
  • Thomas McGlashan
  • Tor K. Larsen
Original Paper

DOI: 10.1007/s00406-012-0308-9

Cite this article as:
Langeveld, J., Joa, I., Friis, S. et al. Eur Arch Psychiatry Clin Neurosci (2012) 262: 599. doi:10.1007/s00406-012-0308-9

Abstract

This study aimed to compare 2-year outcome among individuals with early-onset (EO; <18 years) versus adult-onset (AO) first-episode, non-affective psychosis. We compared clinical and treatment characteristics of 43 EO and 189 AO patients 2 years after their inclusion in a clinical epidemiologic population-based cohort study of first-episode psychosis. Outcome variables included symptom severity, remission status, drug abuse, treatment utilization, cognition and social functioning. At baseline, EO patients were more symptomatically compromised. However, these initial baseline differences were no longer significant at the 2-year follow-up. This study challenges the findings of a larger and older literature base consisting primarily of non-comparative studies concluding that teenage onset indicates a poor outcome. Our results indicate that adolescent-onset and adult-onset psychosis have similar prognostic trajectories, although both may predict a qualitatively different course from childhood-onset psychosis.

Keywords

First-episode psychosis Duration of untreated psychosis Adolescence Early-onset psychosis 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Johannes Langeveld
    • 1
  • Inge Joa
    • 1
  • Svein Friis
    • 2
    • 3
  • Wenche ten Velden Hegelstad
    • 1
  • Ingrid Melle
    • 2
    • 3
  • Jan O. Johannessen
    • 4
  • Stein Opjordsmoen
    • 2
    • 3
  • Erik Simonsen
    • 6
  • Per Vaglum
    • 7
  • Bjørn Auestad
    • 8
  • Thomas McGlashan
    • 9
  • Tor K. Larsen
    • 1
    • 5
  1. 1.Department of Psychiatry, Regional Centre for Clinical Research in PsychosisStavanger University HospitalStavangerNorway
  2. 2.Department of PsychiatryOslo University HospitalOsloNorway
  3. 3.Institute of Psychiatry, Faculty of MedicineUniversity of OsloOsloNorway
  4. 4.Division of PsychiatryStavanger University HospitalStavangerNorway
  5. 5.Department of Clinical Medicine, Section PsychiatryUniversity of BergenBergenNorway
  6. 6.Psychiatric Research Unit, Zealand Region PsychiatryRoskildeDenmark
  7. 7.Department of Behavioural Sciences in Medicine, Faculty of MedicineUniversity of OsloOsloNorway
  8. 8.Faculty of Science and MathematicsUniversity of StavangerStavangerNorway
  9. 9.Department of PsychiatryYale UniversityNew HavenUSA

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