Case–control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics

  • Concetta Crisafulli
  • Alberto Chiesa
  • Changsu Han
  • Soo-Jung Lee
  • Moon Ho Park
  • Beatrice Balzarro
  • Costanza Andrisano
  • Ashwin A. Patkar
  • Chi-Un Pae
  • Alessandro Serretti
Original Paper

DOI: 10.1007/s00406-011-0278-3

Cite this article as:
Crisafulli, C., Chiesa, A., Han, C. et al. Eur Arch Psychiatry Clin Neurosci (2012) 262: 199. doi:10.1007/s00406-011-0278-3

Abstract

The aim of this study is to investigate possible associations between a set of single-nucleotide polymorphisms (SNPs) within 10 genes with Schizophrenia (SCZ) and response to antipsychotics in Korean in-patients treated with antipsychotics. Two hundred and twenty-one SCZ in-patients and 170 psychiatrically healthy controls were genotyped for 42 SNPs within ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. Rs10042486 within 5HTR1A was associated with both SCZ and clinical improvement on PANSS total scores as well as on PANSS positive and PANSS negative scores. The haplotype analyses focusing on the four, three and two blocks’ haplotypes within 5HTR1A confirmed such findings as well. We did not observe any significant association between the remaining genetic variants under investigation in this study and clinical outcomes. Our preliminary findings suggest that rs10042486 within 5HTR1A promoter region could be associated with SCZ and with clinical improvement on PANSS total, positive and negative scores in Korean patients with SCZ. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.

Keywords

Schizophrenia Antipsychotics ABCB1 ABCB4 TAP2 CLOCK CPLX1 CPLX2 SYN2 NRG1 5HTR1A and GPRIN2 

Supplementary material

406_2011_278_MOESM1_ESM.doc (756 kb)
Supplementary material 1 (DOC 756 kb)

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Concetta Crisafulli
    • 1
  • Alberto Chiesa
    • 2
  • Changsu Han
    • 3
  • Soo-Jung Lee
    • 4
  • Moon Ho Park
    • 5
  • Beatrice Balzarro
    • 2
  • Costanza Andrisano
    • 2
  • Ashwin A. Patkar
    • 6
  • Chi-Un Pae
    • 4
    • 6
  • Alessandro Serretti
    • 2
  1. 1.Department of Biomorphology and Biotechnologies, Division of Biology and GeneticsUniversity of MessinaMessinaItaly
  2. 2.Institute of PsychiatryUniversity of BolognaBolognaItaly
  3. 3.Department of Psychiatry, College of MedicineKorea UniversityAnsanRepublic of Korea
  4. 4.Department of Psychiatry, Bucheon St. Mary’s HospitalThe Catholic University of Korea College of MedicineBucheonRepublic of Korea
  5. 5.Department of Neurology, College of MedicineKorea UniversityAnsanRepublic of Korea
  6. 6.Department of Psychiatry and Behavioral SciencesDuke University Medical CenterDurhamUSA

Personalised recommendations