Executive summary of the report by the WPA section on pharmacopsychiatry on general and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders

  • Thomas C. Baghai
  • Pierre Blier
  • David S. Baldwin
  • Michael Bauer
  • Guy M. Goodwin
  • Kostas N. Fountoulakis
  • Siegfried Kasper
  • Brian E. Leonard
  • Ulrik F. Malt
  • Dan J. Stein
  • Marcio Versiani
  • Hans-Jürgen Möller
Original Paper

Abstract

Current gold standard in the treatment of depression includes pharmacotherapeutic and psychotherapeutic strategies together with social support. Due to the actually discussed controversies concerning the differential efficacy of antidepressants, a contribution to a comprehensive clarification seems to be necessary to avert further deterioration and uncertainty from patients, relatives, and their treating psychiatrists and general practitioners. Both efficacy and clinical effectiveness of antidepressants in the treatment of depressive disorders can be confirmed. Clinically meaningful antidepressant treatment effects were confirmed in different types of studies. Methodological issues of randomized controlled studies, meta-analyses, and effectiveness studies will be discussed. Furthermore, actual data about the differential efficacy and effectiveness of antidepressants with distinct pharmacodynamic properties and about outcome differences in studies using antidepressants and/or psychotherapy are discussed. This is followed by a clinically oriented depiction—the differential clinical effectiveness of different pharmacodynamic modes of action of antidepressants in different subtypes of depressive disorders. It can be summarized that the spectrum of different antidepressant treatments has broadened during the last decades. The efficacy and clinical effectiveness of antidepressants is statistically significant and clinically relevant and proven repeatedly. For further optimizing antidepressant treatment plans, clearly structured treatment algorithms and the implementation of psychotherapy seem to be useful. A modern individualized antidepressant treatment in most cases is a well-tolerated and efficacious tool to minimize the negative impact of the otherwise devastating and life-threatening outcome of depressive disorders.

Keywords

Antidepressant treatments Depression Pharmacological treatments Psychotherapy 

References

  1. 1.
    Adli M, Bauer M, Rush AJ (2006) Algorithms and collaborative-care systems for depression: are they effective and why? A systematic review. Biol Psychiatry 59:1029–1038PubMedGoogle Scholar
  2. 2.
    Adli M, Berghofer A, Linden M, Helmchen H, Müller-Oerlinghausen B, Mackert A, Stamm T, Bauer M (2002) Effectiveness and feasibility of a standardized stepwise drug treatment regimen algorithm for inpatients with depressive disorders: results of a 2-year observational algorithm study. J Clin Psychiatry 63:782–790PubMedGoogle Scholar
  3. 3.
    Adli M, Rush AJ, Möller HJ, Bauer M (2003) Algorithms for optimizing the treatment of depression: making the right decision at the right time. Pharmacopsychiatry 36(Suppl 3):S222–S229PubMedGoogle Scholar
  4. 4.
    American Psychiatric Association (2010) http://www.psychiatryonline.com/pracGuide/pracGuideTopic_7.aspx. Accessed 28 Feb 2011
  5. 5.
    Anderson IM (1998) SSRIS versus tricyclic antidepressants in depressed inpatients: a meta-analysis of efficacy and tolerability. Depress Anxiety 7(Suppl 1):11–17PubMedGoogle Scholar
  6. 6.
    Anderson IM (2000) Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability. J Affect Disord 58:19–36PubMedGoogle Scholar
  7. 7.
    Angst J, Angst F, Gerber-Werder R, Gamma A (2005) Suicide in 406 mood-disorder patients with and without long-term medication: a 40 to 44 years’ follow-up. Arch Suicide Res 9:279–300PubMedGoogle Scholar
  8. 8.
    Aronson R, Offman HJ, Joffe RT, Naylor CD (1996) Triiodothyronine augmentation in the treatment of refractory depression. A meta-analysis. Arch Gen Psychiatry 53:842–848PubMedGoogle Scholar
  9. 9.
    Arroll B, Elley CR, Fishman T, Goodyear-Smith FA, Kenealy T, Blashki G, Kerse N, Macgillivray S (2009) Antidepressants versus placebo for depression in primary care. Cochrane Database Syst Rev CD007954Google Scholar
  10. 10.
    Baghai TC, Möller H-J, Rupprecht R (2006) Recent progress in pharmacological and non-pharmacological treatment options of major depression. Curr Pharm Des 12:503–515PubMedGoogle Scholar
  11. 11.
    Baldwin D, Broich K, Fritze J, Kasper S, Westenberg H, Möller HJ (2003) Placebo-controlled studies in depression: necessary, ethical and feasible. Eur Arch Psychiatry Clin Neurosci 253:22–28PubMedGoogle Scholar
  12. 12.
    Barbui C, Furukawa TA, Cipriani A (2008) Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials. CMAJ 2008(01/30):296–305Google Scholar
  13. 13.
    Bauer M, Adli M, Baethge C, Berghofer A, Sasse J, Heinz A, Bschor T (2003) Lithium augmentation therapy in refractory depression: clinical evidence and neurobiological mechanisms. Can J Psychiatry 48:440–448PubMedGoogle Scholar
  14. 14.
    Bauer M, Bschor T, Kunz D, Berghofer A, Strohle A, Müller-Oerlinghausen B (2000) Double-blind, placebo-controlled trial of the use of lithium to augment antidepressant medication in continuation treatment of unipolar major depression. Am J Psychiatry 157:1429–1435PubMedGoogle Scholar
  15. 15.
    Bauer M, Bschor T, Pfennig A, Whybrow PC, Angst J, Versiani M, Möller HJ (2007) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders in primary care. World J Biol Psychiatry 8:67–104PubMedGoogle Scholar
  16. 16.
    Bauer M, Döpfmer S (1999) Lithium augmentation in treatment-resistant depression: meta-analysis of placebo-controlled studies. J Clin Psychopharmacol 19:427–434PubMedGoogle Scholar
  17. 17.
    Bauer M, Pfennig A, Linden M, Smolka MN, Neu P, Adli M (2009) Efficacy of an algorithm-guided treatment compared with treatment as usual: a randomized, controlled study of inpatients with depression. J Clin Psychopharmacol 29:327–333PubMedGoogle Scholar
  18. 18.
    Bauer M, Pretorius HW, Constant EL, Earley WR, Szamosi J, Brecher M (2009) Extended-release quetiapine as adjunct to an antidepressant in patients with major depressive disorder: results of a randomized, placebo-controlled, double-blind study. J Clin Psychiatry 70:540–549PubMedGoogle Scholar
  19. 19.
    Bauer M, Tharmanathan P, Volz HP, Möller HJ, Freemantle N (2009) The effect of venlafaxine compared with other antidepressants and placebo in the treatment of major depression: a meta-analysis. Eur Arch Psychiatry Clin Neurosci 259:172–185PubMedGoogle Scholar
  20. 20.
    Bauer M, Whybrow PC, Angst J, Versiani M, Möller HJ (2002) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 2: maintenance treatment of major depressive disorder and treatment of chronic depressive disorders and subthreshold depressions. World J Biol Psychiatry 3:69–86PubMedGoogle Scholar
  21. 21.
    Bauer M, Whybrow PC, Angst J, Versiani M, WFSBP Task Force on Treatment Guidelines for Unipolar Depressive Disorders (2002) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorder, part 1: acute and continuation treatment of major depressive disorder. World J Biol Psychiatry 3:4–43Google Scholar
  22. 22.
    Berger M, Brakemeier EL, Klesse C, Schramm E (2009) Affective disorders. The significance of psychotherapeutic approaches. Nervenarzt 80:540, 542–540, 548Google Scholar
  23. 23.
    Bschor T, Bauer M (2006) Efficacy and mechanisms of action of lithium augmentation in refractory major depression. Curr Pharm Des 12:2985–2992PubMedGoogle Scholar
  24. 24.
    Calabrese JR, Keck PE Jr, Macfadden W, Minkwitz M, Ketter TA, Weisler RH, Cutler AJ, McCoy R, Wilson E, Mullen J (2005) A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression. Am J Psychiatry 162:1351–1360PubMedGoogle Scholar
  25. 25.
    Canadian Psychiatric Association and Canadian Network for Mood and Anxiety Treatments (CANMAT) (2001) Clinical guidelines for the treatment of depressive disorders. Can J Psychiatry 46:5S–90SGoogle Scholar
  26. 26.
    Charney DS, Grothe DR, Smith SL, Brady KT, Kaltsounis-Puckett J, Wright CW, Laird LK, Rush AJ (2002) Overview of psychiatric disorders and the role of newer antidepressants. J Clin Psychiatry 63:3–9PubMedGoogle Scholar
  27. 27.
    Cipriani A, Barbui C, Brambilla P, Furukawa TA, Hotopf M, Geddes JR (2006) Are all antidepressants really the same? The case of fluoxetine: a systematic review. J Clin Psychiatry 67:850–864PubMedGoogle Scholar
  28. 28.
    Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R, Watanabe N, Nakagawa A, Omori IM, McGuire H, Tansella M, Barbui C (2009) Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet 373:746–758PubMedGoogle Scholar
  29. 29.
    Cipriani A, Santilli C, Furukawa TA, Signoretti A, Nakagawa A, McGuire H, Churchill R, Barbui C (2009) Escitalopram versus other antidepressive agents for depression. Cochrane Database Syst Rev CD006532Google Scholar
  30. 30.
    Compton MT, Nemeroff CB (2000) The treatment of bipolar depression. J Clin Psychiatry 61(Suppl 9):57–67PubMedGoogle Scholar
  31. 31.
    Conte HR, Plutchik R, Wild KV, Karasu TB (1986) Combined psychotherapy and pharmacotherapy for depression. A systematic analysis of the evidence. Arch Gen Psychiatry 43:471–479PubMedGoogle Scholar
  32. 32.
    Cook RJ, Sackett DL (1995) The number needed to treat: a clinically useful measure of treatment effect. BMJ 310:452–454PubMedGoogle Scholar
  33. 33.
    Crossley NA, Bauer M (2007) Acceleration and augmentation of antidepressants with lithium for depressive disorders: two meta-analyses of randomized, placebo-controlled trials. J Clin Psychiatry 68:935–940PubMedGoogle Scholar
  34. 34.
    Cruz N, Sanchez-Moreno J, Torres F, Goikolea JM, Valenti M, Vieta E (2009) Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis. Int J Neuropsychopharmacol 1(13):5–14Google Scholar
  35. 35.
    Cuijpers P, Dekker J, Hollon SD, Andersson G (2009) Adding psychotherapy to pharmacotherapy in the treatment of depressive disorders in adults: a meta-analysis. J Clin Psychiatry 70:1219–1229PubMedGoogle Scholar
  36. 36.
    Cuijpers P, van Straten A, van Oppen P, Andersson G (2008) Are psychological and pharmacologic interventions equally effective in the treatment of adult depressive disorders? A meta-analysis of comparative studies. J Clin Psychiatry 69:1675–1685PubMedGoogle Scholar
  37. 37.
    Cutler AJ, Montgomery SA, Feifel D, Lazarus A, Astrom M, Brecher M (2009) Extended release quetiapine fumarate monotherapy in major depressive disorder: a placebo- and duloxetine-controlled study. J Clin Psychiatry 70:526–539PubMedGoogle Scholar
  38. 38.
    Dam J, Ryde L, Svejso J, Lauge N, Lauritsen B, Bech P (1998) Morning fluoxetine plus evening mianserin versus morning fluoxetine plus evening placebo in the acute treatment of major depression. Pharmacopsychiatry 31:48–54PubMedGoogle Scholar
  39. 39.
    Damm J, Eser D, Schule C, Moller HJ, Rupprecht R, Baghai TC (2009). Core symptoms of depression. Effectiveness of antidepressant therapy. Nervenarzt 80:515–516, 518, 520Google Scholar
  40. 40.
    Danish University Antidepressant Group (1993) Moclobemide: a reversible MAO-A-inhibitor showing weaker antidepressant effect than clomipramine in a controlled multicenter study. J Affect Disord 28:105–116Google Scholar
  41. 41.
    de Mello MF, de Jesus MJ, Bacaltchuk J, Verdeli H, Neugebauer R (2005) A systematic review of research findings on the efficacy of interpersonal therapy for depressive disorders. Eur Arch Psychiatry Clin Neurosci 255:75–82PubMedGoogle Scholar
  42. 42.
    Derry S, Moore RA (2007) Atypical antipsychotics in bipolar disorder: systematic review of randomised trials. BMC Psychiatry 7:40PubMedGoogle Scholar
  43. 43.
    DeRubeis RJ, Gelfand LA, Tang TZ, Simons AD (1999) Medications versus cognitive behaviour therapy for severely depressed outpatients: mega-analysis of four randomized comparisons. Am J Psychiatry 156:1007–1013PubMedGoogle Scholar
  44. 44.
    DeRubeis RJ, Siegle GJ, Hollon SD (2008) Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms. Nat Rev Neurosci 9:788–796PubMedGoogle Scholar
  45. 45.
    DGPPN (2009) http://www.versorgungsleitlinien.de. Accessed 10 Dec 2009
  46. 46.
    Dodd S, Horgan D, Malhi GS, Berk M (2005) To combine or not to combine? A literature review of antidepressant combination therapy. J Affect Disord 89:1–11PubMedGoogle Scholar
  47. 47.
    Edelsberg J, Oster G (2009) Summary measures of number needed to treat: how much clinical guidance do they provide in neuropathic pain? Eur J Pain 13:11–16PubMedGoogle Scholar
  48. 48.
    Elkin I, Gibbons RD, Shea MT, Sotsky SM, Watkins JT, Pilkonis PA, Hedeker D (1995) Initial severity and differential treatment outcome in the National Institute of Mental Health Treatment of depression collaborative research program. J Consult Clin Psychol 63:841–847PubMedGoogle Scholar
  49. 49.
    Ellis P (2004) Australian and New Zealand clinical practice guidelines for the treatment of depression. Aust NZ J Psychiatry 38:389–407Google Scholar
  50. 50.
  51. 51.
    Fava M, Evins AE, Dorer DJ, Schoenfeld DA (2003) The problem of the placebo response in clinical trials for psychiatric disorders: culprits, possible remedies, and a novel study design approach. Psychother Psychosom 72:115–127PubMedGoogle Scholar
  52. 52.
    Fergusson D, Doucette S, Glass KC, Shapiro S, Healy D, Hebert P, Hutton B (2005) Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. BMJ 330:396–402PubMedGoogle Scholar
  53. 53.
    Ferreri M, Lavergne F, Berlin I, Payan C, Puech AJ (2001) Benefits from mianserin augmentation of fluoxetine in patients with major depression non-responders to fluoxetine alone. Acta Psychiatr Scand 103:66–72PubMedGoogle Scholar
  54. 54.
    Fountoulakis KN, Möller HJ (2010) Efficacy of antidepressants: a re-analysis and re-interpretation of the Kirsch data. Int J Neuropsychopharmacol 14(3):405–412Google Scholar
  55. 55.
    Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J (2010) Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 303:47–53PubMedGoogle Scholar
  56. 56.
    Frank E, Grochocinski VJ, Spanier CA, Buysse DJ, Cherry CR, Houck PR, Stapf DM, Kupfer DJ (2000) Interpersonal psychotherapy and antidepressant medication: evaluation of a sequential treatment strategy in women with recurrent major depression. J Clin Psychiatry 61:51–57PubMedGoogle Scholar
  57. 57.
    Fritze J, Möller HJ (2001) Design of clinical trials of antidepressants: should a placebo control arm be included? CNS Drugs 15:755–764PubMedGoogle Scholar
  58. 58.
    Geddes JR, Carney SM, Davies C, Furukawa TA, Kupfer DJ, Frank E, Goodwin GM (2003) Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review. Lancet 361:653–661PubMedGoogle Scholar
  59. 59.
    Gelenberg AJ, Thase ME, Meyer RE, Goodwin FK, Katz MM, Kraemer HC, Potter WZ, Shelton RC, Fava M, Khan A, Trivedi MH, Ninan PT, Mann JJ, Bergeson S, Endicott J, Kocsis JH, Leon AC, Manji HK, Rosenbaum JF (2008) The history and current state of antidepressant clinical trial design: a call to action for proof-of-concept studies. J Clin Psychiatry 69:1513–1528PubMedGoogle Scholar
  60. 60.
    Ghaemi SN (2008) Why antidepressants are not antidepressants: STEP-BD, STAR*D, and the return of neurotic depression. Bipolar Disord 10:957–968PubMedGoogle Scholar
  61. 61.
    Hale A, Corral RM, Mencacci C, Ruiz JS, Severo CA, Gentil V (2010) Superior antidepressant efficacy results of agomelatine versus fluoxetine in severe MDD patients: a randomized, double-blind study. Int Clin Psychopharmacol 25:305–314PubMedGoogle Scholar
  62. 62.
    Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62PubMedGoogle Scholar
  63. 63.
    Hamoda HM, Osser DN (2008) The psychopharmacology algorithm project at the Harvard South Shore Program: an update on psychotic depression. Harv Rev Psychiatry 16:235–247PubMedGoogle Scholar
  64. 64.
    Healy D, Whitaker C (2003) Antidepressants and suicide: risk-benefit conundrums. J Psychiatry Neurosci 28:331–337PubMedGoogle Scholar
  65. 65.
    Hegerl U, Mergl R (2009) The clinical significance of antidepressant treatment effects cannot be derived from placebo-verum response differences. J Psychopharmacol 24(4):445–458Google Scholar
  66. 66.
    Hegerl U, Plattner A, Moller HJ (2004) Should combined pharmaco- and psychotherapy be offered to depressed patients? A qualitative review of randomized clinical trials from the 1990 s. Eur Arch Psychiatry Clin Neurosci 254:99–107PubMedGoogle Scholar
  67. 67.
    Henkel V, Seemuller F, Obermeier M, Adli M, Bauer M, Mundt C, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Mayr A, Möller HJ, Riedel M (2009) Does early improvement triggered by antidepressants predict response/remission? Analysis of data from a naturalistic study on a large sample of inpatients with major depression. J Affect Disord 115:439–449PubMedGoogle Scholar
  68. 68.
    Hirschfeld RM, Dunner DL, Keitner G, Klein DN, Koran LM, Kornstein SG, Markowitz JC, Miller I, Nemeroff CB, Ninan PT, Rush AJ, Schatzberg AF, Thase ME, Trivedi MH, Borian FE, Crits-Christoph P, Keller MB (2002) Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination. Biol Psychiatry 51:123–133PubMedGoogle Scholar
  69. 69.
    Hollon SD, Jarrett RB, Nierenberg AA, Thase ME, Trivedi M, Rush AJ (2005) Psychotherapy and medication in the treatment of adult and geriatric depression: which monotherapy or combined treatment? J Clin Psychiatry 66:455–468PubMedGoogle Scholar
  70. 70.
    Keller MB, McCullough JP, Klein DN, Arnow B, Dunner DL, Gelenberg AJ, Markowitz JC, Nemeroff CB, Russell JM, Thase ME, Trivedi MH, Zajecka J (2000) A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression. N Engl J Med 342:1462–1470PubMedGoogle Scholar
  71. 71.
    Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT (2008) Initial severity and antidepressant benefits: a meta-analysis of data submitted to the food and drug administration. PLoS Med 5:e45PubMedGoogle Scholar
  72. 72.
    Kobayashi N, Sawamura T, Yoshida T, Yoshino A, Nomura S (2004) The effectiveness of lithium augmentation of milnacipran: preliminary data using the modified Japanese psychopharmacology algorithm. Nihon Shinkei Seishin Yakurigaku Zasshi 24:279–281PubMedGoogle Scholar
  73. 73.
    Lau MA (2008) New developments in psychosocial interventions for adults with unipolar depression. Curr Opin Psychiatry 21:30–36PubMedGoogle Scholar
  74. 74.
    Lee MS, Lim SW, Cha JH, Chung SK, Kim KS, Kasper S, Executive Committee for the Korean Medication Algorithm Project for Major Depressive Disorder (2006) Korean medication algorithm for major depressive disorder. Int J Psychiatry Clin Pract 10:186–194Google Scholar
  75. 75.
    Leucht S, Kissling W, Davis JM (2009) How to read and understand and use systematic reviews and meta-analyses. Acta Psychiatr Scand 119:443–450PubMedGoogle Scholar
  76. 76.
    Melander H, Salmonson T, Abadie E, van Zwieten-Boot B (2008) A regulatory Apologia–a review of placebo-controlled studies in regulatory submissions of new-generation antidepressants. Eur Neuropsychopharmacol 18:623–627PubMedGoogle Scholar
  77. 77.
    Möller HJ (2008) Isn’t the efficacy of antidepressants clinically relevant? A critical comment on the results of the metaanalysis by Kirsch et al. 2008. Eur Arch Psychiatry Clin Neurosci 258:451–455PubMedGoogle Scholar
  78. 78.
    Möller HJ, Grunze H, Broich K (2006) Do recent efficacy data on the drug treatment of acute bipolar depression support the position that drugs other than antidepressants are the treatment of choice? A conceptual review. Eur Arch Psychiatry Clin Neurosci 256:1–16PubMedGoogle Scholar
  79. 79.
    Möller HJ, Maier W (2010) Evidence-based medicine in psychopharmacotherapy: possibilities, problems and limitations. Eur Arch Psychiatry Clin Neurosci 260:25–39PubMedGoogle Scholar
  80. 80.
    Moncrieff J, Wessely S, Hardy R (2004) Active placebos versus antidepressants for depression. Cochrane Database Syst Rev CD003012Google Scholar
  81. 81.
    Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389PubMedGoogle Scholar
  82. 82.
    Montgomery SA, Baldwin DS, Blier P, Fineberg NA, Kasper S, Lader M, Lam RW, Lepine JP, Moller HJ, Nutt DJ, Rouillon F, Schatzberg AF, Thase ME (2007) Which antidepressants have demonstrated superior efficacy? A review of the evidence. Int Clin Psychopharmacol 22:323–329PubMedGoogle Scholar
  83. 83.
    Mukai Y, Tampi RR (2009) Treatment of depression in the elderly: a review of the recent literature on the efficacy of single- versus dual-action antidepressants. Clin Ther 31:945–961PubMedGoogle Scholar
  84. 84.
    Muller-Oerlinghausen B, Lewitzka U (2010) Lithium reduces pathological aggression and suicidality: a mini-review. Neuropsychobiology 62:43–49PubMedGoogle Scholar
  85. 85.
    National Collaborating Centre for Mental Health (2009) London, National Institute for Health and Clinical Excellence (NICE). http://guidance.nice.org.uk/CG90. Accessed 7 Dec 2009
  86. 86.
    National Institute for Clinical Excellence (2004) http://www.nice.org.uk/nicemedia/pdf/CG23fullguideline.pdf. Accessed 1 December 2010
  87. 87.
    Nelson JC, Docherty JP, Henschen GM, Kasper S, Nierenberg AA, Ward NG (1995) Algorithms for the treatment of subtypes of unipolar major depression. Psychopharmacol Bull 31:475–482PubMedGoogle Scholar
  88. 88.
    Nelson JC, Papakostas GI (2009) Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials. Am J Psychiatry 166:980–991PubMedGoogle Scholar
  89. 89.
    Nierenberg AA, Ostacher MJ, Huffman JC, Ametrano RM, Fava M, Perlis RH (2008) A brief review of antidepressant efficacy, effectiveness, indications, and usage for major depressive disorder. J Occup Environ Med 50:428–436PubMedGoogle Scholar
  90. 90.
    Ostacher MJ (2006) The evidence for antidepressant use in bipolar depression. J Clin Psychiatry 67(Suppl 11):18–21PubMedGoogle Scholar
  91. 91.
    Pampallona S, Bollini P, Tibaldi G, Kupelnick B, Munizza C (2004) Combined pharmacotherapy and psychological treatment for depression: a systematic review. Arch Gen Psychiatry 61:714–719PubMedGoogle Scholar
  92. 92.
    Papakostas GI (2007) Augmentation strategies in the treatment of major depressive disorder. Examining the evidence on augmentation with atypical antipsychotics. CNS Spectr 12:10–12PubMedGoogle Scholar
  93. 93.
    Papakostas GI (2009) Pharmacologic and therapeutic strategies in treatment-resistant depression. Switching antidepressants vs. conventional augmentation strategies. CNS Spectr 14:11–14PubMedGoogle Scholar
  94. 94.
    Papakostas GI, Thase ME, Fava M, Nelson JC, Shelton RC (2007) Are antidepressant drugs that combine serotonergic and noradrenergic mechanisms of action more effective than the selective serotonin reuptake inhibitors in treating major depressive disorder? A meta-analysis of studies of newer agents. Biol Psychiatry 62:1217–1227PubMedGoogle Scholar
  95. 95.
    Parker G, Parker I, Brotchie H, Stuart S (2006) Interpersonal psychotherapy for depression? The need to define its ecological niche. J Affect Disord 95:1–11PubMedGoogle Scholar
  96. 96.
    Price LH, Conwell Y, Nelson JC (1983) Lithium augmentation of combined neuroleptic-tricyclic treatment in delusional depression. Am J Psychiatry 140:318–322PubMedGoogle Scholar
  97. 97.
    Reeves RR, Ladner ME (2010) Antidepressant-induced suicidality: an update. CNS Neurosci Ther 16:227–234PubMedGoogle Scholar
  98. 98.
    Rihmer Z, Akiskal H (2006) Do antidepressants t(h)reat(en) depressives? Toward a clinically judicious formulation of the antidepressant-suicidality FDA advisory in light of declining national suicide statistics from many countries. J Affect Disord.:Google Scholar
  99. 99.
    Rush AJ, Crismon ML, Kashner TM, Toprac MG, Carmody TJ, Trivedi MH, Suppes T, Miller AL, Biggs MM, Shores-Wilson K, Witte BP, Shon SP, Rago WV, Altshuler KZ (2003) Texas medication algorithm project, phase 3 (TMAP-3): rationale and study design. J Clin Psychiatry 64(4):357–369PubMedGoogle Scholar
  100. 100.
    Rush AJ, Thase ME (1997) Strategies and tactics in the treatment of chronic depression. J Clin Psychiatry 58(Suppl 13):14–22PubMedGoogle Scholar
  101. 101.
    Rush AJ, Trivedi M, Fava M (2003) Depression, IV: STAR*D treatment trial for depression. Am J Psychiatry 160:237PubMedGoogle Scholar
  102. 102.
    Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, Niederehe G, Thase ME, Lavori PW, Lebowitz BD, McGrath PJ, Rosenbaum JF, Sackeim HA, Kupfer DJ, Luther J, Fava M (2006) Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry 163:1905–1917PubMedGoogle Scholar
  103. 103.
    Sartorius N, Baghai TC, Baldwin DS, Barrett B, Brand U, Fleischhacker W, Goodwin G, Grunze H, Knapp M, Leonard BE, Lieberman J, Nakane Y, Pinder RM, Schatzberg AF, Svestka J, Baumann P, Ghalib K, Markowitz JC, Padberg F, Fink M, Furukawa T, Fountoulakis KN, Jensen P, Kanba S, Riecher-Rossler A (2007) Antidepressant medications and other treatments of depressive disorders: a CINP Task Force report based on a review of evidence. Int J Neuropsychopharmacol 10(Suppl 1):S1–S207PubMedGoogle Scholar
  104. 104.
    Seemüller F, Riedel M, Obermeier M, Bauer M, Adli M, Kronmuller K, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Dichgans E, Bottlander R, Musil R, Möller HJ (2010) Outcomes of 1014 naturalistically treated inpatients with major depressive episode. Eur Neuropsychopharmacol 20(5):346–355Google Scholar
  105. 105.
    Seyringer ME, Kasper S (2009) Ranking antidepressants. Lancet 373:1760–1761PubMedGoogle Scholar
  106. 106.
    Simon GE, Savarino J (2007) Suicide attempts among patients starting depression treatment with medications or psychotherapy. Am J Psychiatry 164:1029–1034PubMedGoogle Scholar
  107. 107.
    Souery D, Amsterdam J, de Montigny C, Lecrubier Y, Montgomery S, Lipp O, Racagni G, Zohar J, Mendlewicz J (1999) Treatment resistant depression: methodological overview and operational criteria. Eur Neuropsychopharmacol 9:83–91PubMedGoogle Scholar
  108. 108.
    Storosum JG, Elferink AJ, van Zwieten BJ, van den Brink W, Gersons BP, van Strik R, Broekmans AW (2001) Short-term efficacy of tricyclic antidepressants revisited: a meta-analytic study. Eur Neuropsychopharmacol 11:173–180PubMedGoogle Scholar
  109. 109.
    Stübner S, Grohmann R, von Stralendorff I, Ruther E, Moller HJ, Muller-Oerlinghausen B, Engel RR, Horvath A, Greil W (2010) Suicidality as rare adverse event of antidepressant medication: report from the AMSP multicenter drug safety surveillance project. J Clin Psychiatry 71:1293–1307PubMedGoogle Scholar
  110. 110.
    Thase ME, Macfadden W, Weisler RH, Chang W, Paulsson B, Khan A, Calabrese JR (2006) Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study). J Clin Psychopharmacol 26:600–609PubMedGoogle Scholar
  111. 111.
    Thase ME, Rush AJ (1997) When at first you don’t succeed: sequential strategies for antidepressant nonresponders. J Clin Psychiatry 58(Suppl 13):23–29PubMedGoogle Scholar
  112. 112.
    Trivedi MH, Daly EJ (2007) Measurement-based care for refractory depression: a clinical decision support model for clinical research and practice. Drug Alcohol Depend 88(Suppl 2):S61–S71PubMedGoogle Scholar
  113. 113.
    Trivedi MH, Fava M, Wisniewski SR, Thase ME, Quitkin F, Warden D, Ritz L, Nierenberg AA, Lebowitz BD, Biggs MM, Luther JF, Shores-Wilson K, Rush AJ (2006) Medication augmentation after the failure of SSRIs for depression. N Engl J Med 354:1243–1252PubMedGoogle Scholar
  114. 114.
    Trivedi MH, Rush AJ, Crismon ML, Kashner TM, Toprac MG, Carmody TJ, Key T, Biggs MM, Shores-Wilson K, Witte B, Suppes T, Miller AL, Altshuler KZ, Shon SP (2004) Clinical results for patients with major depressive disorder in the Texas medication algorithm project. Arch Gen Psychiatry 61:669–680PubMedGoogle Scholar
  115. 115.
    Turner E, Moreno SG, Sutton AJ (2009) Ranking antidepressants. Lancet 373:1760–1762PubMedGoogle Scholar
  116. 116.
    Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R (2008) Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med 358:252–260PubMedGoogle Scholar
  117. 117.
    U.S.Food and Drug Administration (FDA) (2007) http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm096273.htm. Accessed 31 Jan 2011
  118. 118.
  119. 119.
    Uchida H, Takeuchi H, Suzuki T, Nomura K, Watanabe K, Kashima H (2005) Combined treatment with sulpiride and paroxetine for accelerated response in patients with major depressive disorder. J Clin Psychopharmacol 25:545–551PubMedGoogle Scholar
  120. 120.
    Walsh BT, Seidman SN, Sysko R, Gould M (2002) Placebo response in studies of major depression: variable, substantial, and growing. JAMA 287:1840–1847PubMedGoogle Scholar
  121. 121.
    Weissman MM (1979) The psychological treatment of depression. Evidence for the efficacy of psychotherapy alone, in comparison with, and in combination with pharmacotherapy. Arch Gen Psychiatry 36:1261–1269PubMedGoogle Scholar
  122. 122.
    Weissman MM, Prusoff BA, Dimascio A, Neu C, Goklaney M, Klerman GL (1979) The efficacy of drugs and psychotherapy in the treatment of acute depressive episodes. Am J Psychiatry 136:555–558PubMedGoogle Scholar
  123. 123.
    Wisniewski SR, Rush AJ, Nierenberg AA, Gaynes BN, Warden D, Luther JF, McGrath PJ, Lavori PW, Thase ME, Fava M, Trivedi MH (2009) Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR*D report. Am J Psychiatry 166:599–607PubMedGoogle Scholar
  124. 124.
    Workman EA, Short DD (1993) Atypical antidepressants versus imipramine in the treatment of major depression: a meta-analysis. J Clin Psychiatry 54:5–12PubMedGoogle Scholar
  125. 125.
  126. 126.
    Young AH, McElroy SL, Bauer M, Philips N, Chang W, Olausson B, Paulsson B, Brecher M (2010) A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I). J Clin Psychiatry 71:150–162PubMedGoogle Scholar
  127. 127.
    Zullino D, Baumann P (2001) Lithium augmentation in depressive patients not responding to selective serotonin reuptake inhibitors. Pharmacopsychiatry 34:119–127PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Thomas C. Baghai
    • 1
    • 2
  • Pierre Blier
    • 3
  • David S. Baldwin
    • 4
  • Michael Bauer
    • 5
  • Guy M. Goodwin
    • 6
  • Kostas N. Fountoulakis
    • 7
  • Siegfried Kasper
    • 8
  • Brian E. Leonard
    • 9
  • Ulrik F. Malt
    • 10
  • Dan J. Stein
    • 11
  • Marcio Versiani
    • 12
  • Hans-Jürgen Möller
    • 1
  1. 1.Department of Psychiatry and PsychotherapyLudwig-Maximilian-University of MunichMunichGermany
  2. 2.Department of Psychiatry and PsychotherapyUniversity RegensburgRegensburgGermany
  3. 3.Department of PsychiatryUniversity of OttawaOttawaCanada
  4. 4.University Department of PsychiatryUniversity of SouthamptonSouthamptonUK
  5. 5.University Hospital Carl Gustav CarusDresdenGermany
  6. 6.University DepartmentWarneford HospitalOxfordUK
  7. 7.3rd Department of PsychiatryAristotle University of ThessalonikiThessalonikiGreece
  8. 8.Department of Psychiatry and PsychotherapyMedical University of ViennaViennaAustria
  9. 9.National University of IrelandGalwayIreland
  10. 10.Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University HospitalUniversity of OsloOsloNorway
  11. 11.MRC Unit of Anxiety DisordersUniversity of StellenboschCape TownSouth Africa
  12. 12.Department of PsychiatryFederal University of Rio de JaneiroRio de JaneiroBrazil

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