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Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity

  • Johann Steiner
  • Roland Jacobs
  • Benjamin Panteli
  • Mareike Brauner
  • Kolja Schiltz
  • Sabine Bahn
  • Marlis Herberth
  • Sabine Westphal
  • Tomasz Gos
  • Martin Walter
  • Hans-Gert Bernstein
  • Aye Mu Myint
  • Bernhard Bogerts
Original Paper

Abstract

Previous studies of lymphocyte distribution in schizophrenia have yielded inconsistent results, as summarized in the present study. Based on our own original data, potential confounds that might explain these variations are analyzed and discussed. Blood samples from 26 patients with acute paranoid schizophrenia were investigated in comparison with 32 matched healthy controls by flow cytometry (CD3, CD4, CD8, CD19, and CD56 phenotyping). A subgroup of drug-free patients was followed up after 6 weeks of treatment. Cotinine levels and the free cortisol index (FCI) were provided in order to control for medication, smoking, and stress. Cotinine levels correlated with natural killer (NK) cell counts (CD3/CD56+: r = −0.383, P = 0.003) while the FCI was related to B cell numbers (CD19+: r = 0.390, P = 0.003). Considering these covariates, a lower level of T helper cells (P = 0.010), a reduced CD4/CD8 ratio (P = 0.029), and elevated B cells (P = 0.008) were found during acute psychosis. After 6 weeks of medication, an inverse pattern was observed in initially drug-free patients: total T cell (P = 0.005), T helper (P = 0.003), and T suppressor/cytotoxic cells (P = 0.005) increased, while B cell counts declined (P = 0.049). In conclusion, acute paranoid schizophrenia may be accompanied by a reduced T cell defense and a shift towards B cell immunity, which normalizes in response to treatment. In addition to disease stage or subtype and medication, cigarette smoking and stress are important co-factors.

Keywords

Schizophrenia Flow cytometry Lymphocytes Medication Smoking Stress Review 

Notes

Acknowledgments

This work was supported in part by grants of the Saxony-Anhalt Ministry of Research (Grant No. XN3594O/0405M, N2-OGU) and Stanley Medical Research Foundation (Grant No. 07R-1832) to BB and JS. We thank Hendrik Bielau (HB) for his diagnostic re-assessment of schizophrenia cases and are grateful to Henrik Dobrowolny for his skillful assistance in statistical analysis.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Johann Steiner
    • 1
  • Roland Jacobs
    • 2
  • Benjamin Panteli
    • 1
  • Mareike Brauner
    • 1
  • Kolja Schiltz
    • 1
  • Sabine Bahn
    • 3
  • Marlis Herberth
    • 3
  • Sabine Westphal
    • 4
  • Tomasz Gos
    • 1
    • 5
  • Martin Walter
    • 1
  • Hans-Gert Bernstein
    • 1
  • Aye Mu Myint
    • 6
  • Bernhard Bogerts
    • 1
  1. 1.Department of PsychiatryUniversity of MagdeburgMagdeburgGermany
  2. 2.Institute of Clinical Immunology and Rheumatology, Hannover Medical SchoolHannoverGermany
  3. 3.Institute of BiotechnologyUniversity of CambridgeCambridgeUK
  4. 4.Institute of Clinical Chemistry and PathobiochemistryUniversity of MagdeburgMagdeburgGermany
  5. 5.Institute of Forensic MedicineMedical University of GdanskGdanskPoland
  6. 6.Department of PsychiatryUniversity of MunichMunichGermany

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