Cannabis use in pregnancy and early life and its consequences: animal models

Special Issue

Abstract

Cannabinoid receptors and their endogenous ligands have been detected from the earliest stages of embryonic development. The endocannabinoid system appears to play essential roles in these early stages for neuronal development and cell survival, although its detailed involvement in fundamental developmental processes such as proliferation, migration and differentiation has not yet been completely understood. Therefore, it is not surprising that manipulations of the endocannabinoid system by cannabinoid exposure during early developmental stages can result in long-lasting neurobehavioural consequences. The present review will summarize the possible residual behavioural effects of cannabinoid administration during pre- and perinatal as well as early postnatal development, derived from animal studies.

Keywords

Cannabinoids Prenatal Postnatal CB1 receptor Pregnancy Animal models 

Abbreviations

BGS

Brain growth spurt

CBD

Cannabidiol

CPP

Conditioned place preference

CP

CP 55,940

EPM

Elevated plus maze

FST

Forced swim test

GD

Gestational day

PD

Postnatal day

PR

Progressive ratio

THC

Δ9-Tetrahydrocannabinol

USV

Ultrasonic vocalization

WIN

WIN 55,212-2

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of PsychopharmacologyCentral Institute of Mental Health (ZI)MannheimGermany

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