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From genes to psychoses and back: the role of the 5HT2α-receptor and prepulse inhibition in schizophrenia

  • Wolfgang MaierEmail author
  • Rainald Mössner
  • Boris B. Quednow
  • Michael Wagner
  • René Hurlemann
Article

Abstract

Decomposition of schizophrenia into neurobiological vulnerability traits is necessary to understand the complex genetic underpinnings of this phenomenologically defined disorder. This issue is discussed with a focus on prepulse inhibition (PPI) as a neurobiological phenotype and the 5HT2a-receptor as a candidate gene. A series of recent studies illuminates that PPI and 5HT2a-receptors present as vulnerability markers for schizophrenia; a functional sequence variant in the 5HT2a-gene is contributing to this relationship and might consequently contribute to the genetic predisposition to schizophrenia with a very small risk increase.

Keywords

schizophrenia endophenotypes prepulse inhibition serotonin 2α-receptor (5HT2a) 5HT2a-gene 

Notes

Conflict of interest statement

The authors have no conflict of interest to declare.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Wolfgang Maier
    • 1
    Email author
  • Rainald Mössner
    • 1
  • Boris B. Quednow
    • 1
  • Michael Wagner
    • 1
  • René Hurlemann
    • 1
  1. 1.Klinik und Poliklinik für Psychiatrie und Psychotherapie, der Universität BonnBonnGermany

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