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Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population

  • Xenia GondaEmail author
  • Konstantinos N. Fountoulakis
  • Gabriella Juhasz
  • Zoltan Rihmer
  • Judit Lazary
  • Andras Laszik
  • Hagop S. Akiskal
  • Gyorgy Bagdy
ORIGINAL PAPER

Abstract

Introduction

Research concerning the genetic background of traits, temperaments and psychiatric disorders has been rapidly expanding. One of the most frequently studied genetic polymorphisms in the background of psychological and psychiatric phenomena is the 5-HTTLPR polymorphism of the serotonin transporter gene which has earlier been found to be associated with neuroticism and neuroticism-related traits and disorders. However, both the neuroticism trait and psychiatric disorders are complex and composed of several subfacets. The aim of our study was to investigate the association of the 5-HTTLPR polymorphism with several smaller, distinct and better characterisable phenomena related to the neuroticism trait.

Methods

169 healthy females participated in the study. All participants completed the Buss–Durkee Hostility Inventory (BDHI), the State-Trait Anxiety Inventory (STAI), The Zung Self-rating Depression Scale (ZSDS), the Beck Hopelessness Scale, the SCL-51, the Temperament and Character Inventory (TCI) and the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A) questionnaire. All subjects were genotyped for the 5-HTTLPR using PCR. Data were analysed with ANOVA and MANCOVA with age as a covariate.

Results

We found that the presence of the s allele was significantly associated with anxiety, depression, hopelessness, guilt, hostility, aggression, presence of neurotic symptoms, self-directedness and affective temperaments carrying a depressive component even when controlling for age.

Conclusions

Our study is the first that confirms that traits and characteristics related to neuroticism, such as increased anxiety, depression, hopelessness, somatization, feeling of guilt, hostility, aggression, lack of self-directedness and affective temperament are consistently and independently associated with the 5-HTTLPR polymorphism of the serotonin transporter gene. Our study therefore suggests that neuroticism can be considered a unified construct not only from a phenotypical but also from a genetic point of view and 5HTTLPR can be considered one component of its polygenic background. Our results thus yield further insight into the role of the 5-HTTLPR in the background of neuroticism and neuroticism-related psychiatric disorders.

Keywords

5-HTTLPR polymorphism neuroticism affective temperaments 

Notes

Acknowledgments

These studies were supported by the Sixth Framework Programme of the EU, LSHM-CT-2004-503474, the Ministry of Welfare Research Grant 460/2006, the Hungarian Research Fund Grants 022256/1997 and 032398/2000 and the PhD Fellowship Program of the Semmelweis University, Ministry of Culture and Education, Hungary. The authors wish to thank Sandor Rozsa and Eszter Molnár for their help and advice concerning the manuscript.

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Copyright information

© Steinkopff Verlag Darmstadt 2008

Authors and Affiliations

  • Xenia Gonda
    • 1
    • 2
    Email author
  • Konstantinos N. Fountoulakis
    • 3
  • Gabriella Juhasz
    • 4
  • Zoltan Rihmer
    • 1
  • Judit Lazary
    • 2
  • Andras Laszik
    • 5
  • Hagop S. Akiskal
    • 6
    • 7
    • 8
  • Gyorgy Bagdy
    • 2
    • 9
  1. 1.Dept. of Clinical and Theoretical Mental Health, Kutvolgyi Clinical CentreSemmelweis UniversityBudapestHungary
  2. 2.Dept. of Pharmacology and PharmacotherapySemmelweis UniversityBudapestHungary
  3. 3.3rd Dept. of PsychiatryAristotle University, University Hospital AHEPAThessalonikiGreece
  4. 4.Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human SciencesThe University of ManchesterManchesterUK
  5. 5.Institute of Forensic MedicineSemmelweis UniversityBudapestHungary
  6. 6.International Mood CenterLa JollaUSA
  7. 7.Union of Depressive and Manic-depressive AssociationRennesFrance
  8. 8.Dept. of PsychiatryUniversity of California at San DiegoLa JollaUSA
  9. 9.Group of Neuropsychopharmacology, Hungarian Academy of SciencesSemmelweis UniversityBudapestHungary

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