Anterior hippocampus orchestrates successful encoding and retrieval of non-relational memory: an event-related fMRI study

  • Tilo Kircher
  • Susanne Weis
  • Dirk Leube
  • Katrin Freymann
  • Michael Erb
  • Frank Jessen
  • Wolfgang Grodd
  • Reinhard Heun
  • Sören Krach


Episodic memory encoding and retrieval processes have been linked to different neural networks. However, the common brain regions associated with non-relational memory processing during successful encoding (subsequent memory effect) and successful retrieval (recognition effect) have not yet been investigated. Further, the majority of functional imaging studies have been conducted in young subjects, whereas patients from lesion studies, where most neuropsychological models are still based upon, are usually older. Inferences from younger subjects cannot necessarily be applied to the elderly, an issue becoming particularly relevant with our ageing society. Using an event-related fMRI approach we studied 29 healthy elderly subjects (mean age 67.8, SD 5.4 years) with a non-associative task of intentional word list encoding and retrieval. For each subject, behavioural responses were individually classified into four event types (hits test, misses test, false alarms, correct rejections). Brain areas activated during successful memory encoding comprised the anterior left hippocampus extending into the surrounding parahippocampal gyrus. Regions associated with successful memory retrieval involved a wide-spread network of anterior left parahippocampal gyrus, bilateral temporal cortices and bilateral ventral and dorsal prefrontal areas. Regions contributing to both successful encoding and retrieval, evidenced by a conjunction analysis, revealed prominent left lateralized activations of the anterior hippocampus and the inferior parietal lobe. Our results indicate that the anterior left hippocampus plays an important role during successful memory encoding and during successful memory retrieval in a task of simple, non-associative wordlist learning in healthy elderly subjects.


non-relational memory hippocampus er-fMRI 



The study was supported by grants from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG Nr. HE 2318/4-1 and GR 833/7-1) and by a grant from the Interdisciplinary Center for Clinical Research “BIOMAT.” within the Faculty of Medicine at the RWTH Aachen University (IZKF VV N68).


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Copyright information

© Springer 2008

Authors and Affiliations

  • Tilo Kircher
    • 1
  • Susanne Weis
    • 2
  • Dirk Leube
    • 1
  • Katrin Freymann
    • 3
  • Michael Erb
    • 4
  • Frank Jessen
    • 3
  • Wolfgang Grodd
    • 4
  • Reinhard Heun
    • 5
  • Sören Krach
    • 1
    • 6
  1. 1.Department of PsychiatryRWTH Aachen University HospitalAachenGermany
  2. 2.Department of NeurologyRWTH Aachen University HospitalAachenGermany
  3. 3.Department of PsychiatryUniversity of BonnBonnGermany
  4. 4.Section of Experimental Magnetic Resonance of CNS, Department of NeuroradiologyUniversity of TuebingenTuebingenGermany
  5. 5.Department of PsychiatryUniversity of BirminghamBirminghamUK
  6. 6.Central Service Facility “Functional Imaging” at the ICCR-BiomatRWTH Aachen University HospitalAachenGermany

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