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Cerebral connectivity and psychotic personality traits

A diffusion tensor imaging study
  • Umberto Volpe
  • Andrea FederspielEmail author
  • Armida Mucci
  • Thomas Dierks
  • Anders Frank
  • Lars-Olof Wahlund
  • Silvana Galderisi
  • Mario Maj
ORIGINAL PAPER

Abstract

This study aims to investigate the relationship between regional connectivity in the brain white matter and the presence of psychotic personality traits, in healthy subjects with psychotic traits. Thirteen healthy controls were administered the MMPI-2, to assess psychotic traits and, according to MMPI results, a dichotomization into a group of “high-psychotic” and “low-psychotic” was performed. Diffusion tensor imaging (DTI) was used as a non-invasive measure, in order to obtain information about the fractional anisotropy (FA), an intravoxel index of local connectivity and, by means of a voxelwise approach, the between-group differences of the FA values were calculated. The “high-psychotic” group showed higher FA in the left arcuate fasciculus. Subjects with low scores for psychotic traits had significantly higher FA in the corpus callosum, right arcuate fasciculus, and fronto-parietal fibers. In line with previous brain imaging studies of schizophrenia spectrum disorders, our results suggest that psychotic personality traits are related to altered connectivity and brain asymmetry.

Keywords

brain connectivity brain asymmetry diffusion tensor imaging (DTI) fractional anisotropy personality assessment psychotic personality traits psychosis schizophrenia spectrum 

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Copyright information

© Springer 2008

Authors and Affiliations

  • Umberto Volpe
    • 1
    • 3
  • Andrea Federspiel
    • 2
    • 3
    Email author
  • Armida Mucci
    • 1
  • Thomas Dierks
    • 2
    • 3
  • Anders Frank
    • 3
    • 4
  • Lars-Olof Wahlund
    • 3
  • Silvana Galderisi
    • 1
  • Mario Maj
    • 1
  1. 1.Department of PsychiatryUniversity of Naples SUNNaplesItaly
  2. 2.Department of Psychiatric NeurophysiologyUniversity Hospital of Psychiatry, University of BernBern 60Switzerland
  3. 3.Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (Neurotec), Division of Clinical Geriatrics, Karolinska InstituteHuddinge University HospitalStockholmSweden
  4. 4.Department of Hospital Physics, Karolinska InstituteHuddinge University HospitalStockholmSweden

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