Gene-environment interaction and the anxiety disorders

  • Richie PoultonEmail author
  • Gavin Andrews
  • Jane Millichamp

In this Special Issue a number of leading anxiety researchers have critically reviewed attempts to discover replicable gene-environment interactions (G × E) for the anxiety disorders. They present cogent summaries of what is and what is not known about G × E for each of the anxiety disorders. They have also identified major stumbling blocks to progress, and offered practical suggestions for overcoming these challenges. Some illustrate strategies for better integrating epidemiological and experimental research to advance understanding. Together, they provide a splendid ‘stocktake’ of where the field currently is, as well as tantalising us with glimpses of what might be just over the horizon. By way of introduction to this series, we highlight several key issues confronting research seeking to model the complexity of nature–nurture interplay [44].

How best to conceptualise and measure the anxiety phenotype?

The anxiety disorders are the commonest class of mental disorder. The main groups...


Anxiety Disorder Obsessive Compulsive Disorder Social Phobia Panic Disorder Obsessive Compulsive Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2008

Authors and Affiliations

  • Richie Poulton
    • 1
    Email author
  • Gavin Andrews
    • 2
  • Jane Millichamp
    • 3
  1. 1.Dunedin Multidisciplinary Health & Development Research Unit, Department of Preventive & Social MedicineDunedin School of Medicine, University of OtagoDunedinNew Zealand
  2. 2.Department of PsychiatryUniversity of New South WalesSydneyAustralia
  3. 3.Department of Psychological MedicineUniversity of OtagoDunedinNew Zealand

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