Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?

  • H. Georg Kuhn
  • Christi M. Cooper-Kuhn
  • Karin Boekhoorn
  • Paul J. Lucassen
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Abstract

Alzheimer’s disease and related dementias are devastating disorders that lead to the progressive decline of cognitive functions. Characteristic features are severe brain atrophy, paralleled by accumulation of beta amyloid and neurofibrillary tangles. With the discovery of neurogenesis in the adult brain, the hopes have risen that these neurodegenerative conditions could be overcome, or at least ameliorated, by the generation of new neurons. The location of the adult neurogenic zones in the hippocampus and the lateral ventricle wall, close to corpus callosum and neocortex, indicates strategic positions for potential repair processes. However, we also need to consider that the generation of new neurons is possibly involved in cognitive functions and could, therefore, be influenced by disease pathology. Moreover, aberrant neurogenic mechanisms could even be a part of the pathological events of neurodegenerative diseases. It is the scope of this review to summarize and analyze the recent data from neurogenesis research with respect to Alzheimer’s disease and its animal models.

Keywords

Alzheimer’s disease neuronal progenitor cells amyloid precursor protein tau presenilin 

Abbreviations

AD

Alzheimer’s disease

APP

amyloid precursor protein

beta amyloid peptide

BDNF

brain derived neurotrophic factor

BrdU

bromo-deoxyuridine

CA

cornu ammonis

CNS

central nervous system

DCX

doublecortin

DG

dentate gyrus

FGF-2

fibroblast growth factor 2

IGF-1

insulin-like growth factor 1

LTP

long-term potentiation

MAP

microtubule-associated protein

NFT

neurofibrillary tangle

PCNA

proliferating cell nuclear antigen

PDGF

platelet-derived growth factor

PS

presenilin

RMS

rostral migratory stream

SGZ

subgranular zone

SVZ

subventricular zone

VEGF

vascular endothelial growth factor

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Copyright information

© Springer 2007

Authors and Affiliations

  • H. Georg Kuhn
    • 1
  • Christi M. Cooper-Kuhn
    • 1
  • Karin Boekhoorn
    • 2
  • Paul J. Lucassen
    • 2
  1. 1.Center for Brain Repair and Rehabilitation Institute for Neuroscience and PhysiologyGöteborg UniversityGöteborgSweden
  2. 2.Swammerdam Institute for Neuroscience Centre for NeuroscienceUniversity of AmsterdamAmsterdamThe Netherlands

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