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Reduced planum temporale volume and delusional behaviour in patients with schizophrenia

  • Syudo Yamasaki
  • Hidenori Yamasue
  • Osamu Abe
  • Haruyasu Yamada
  • Akira Iwanami
  • Yoshio Hirayasu
  • Motoaki Nakamura
  • Shun-ichi Furukawa
  • Mark A. Rogers
  • Yoshihiko Tanno
  • Shigeki Aoki
  • Nobumasa Kato
  • Kiyoto Kasai
ORIGINAL PAPER

Abstract

The structural abnormality of planum temporale (PT), a part of the superior temporal heteromodal association cortex involved in auditory and language processing, has been implicated in the pathophysiology of schizophrenia. However, its relationship to clinical manifestations remains unclear. Magnetic resonance images were obtained from 17 right-handed Japanese men with schizophrenia and from 22 age-, handedness-, and parental socioeconomic-status-matched healthy Japanese men in order to manually evaluate grey matter volumes of Heschl’s gyrus (HG) and PT. Psychiatric symptoms were assessed using positive and negative syndrome scale among the patients. Compared with healthy participants, patients with schizophrenia were associated with a statistically significant PT grey matter volume reduction without left or right lateralization, whereas HG volume was preserved. Smaller right PT volume was significantly correlated with more severe delusional behaviour in the patients. Previous investigations have focused on smaller-than-normal left PT in the pathophysiology of schizophrenia; however, the present results suggest a possible role of the right PT, which is involved in social cognition such as understanding the intentions of others, in the production of psychotic experiences in patients with schizophrenia.

Key words

schizophrenia MRI planum temporale superior temporal gyrus delusion 

Notes

Acknowledgements

This study was supported by grants-in-aid for scientific research (No. 18019009 and 18390319 to KK, No. 17-5234 to MAR) from the JSPS and the MEXT, and by grants-in-aid (H17-Kokoro-Ippan 009, H18-Shi 7, H17-Koh 2 to KK) from the Ministry of Health, Labor and Welfare, Japan.

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Copyright information

© Springer 2007

Authors and Affiliations

  • Syudo Yamasaki
    • 1
  • Hidenori Yamasue
    • 2
  • Osamu Abe
    • 3
  • Haruyasu Yamada
    • 3
  • Akira Iwanami
    • 4
  • Yoshio Hirayasu
    • 5
  • Motoaki Nakamura
    • 6
  • Shun-ichi Furukawa
    • 1
  • Mark A. Rogers
    • 2
  • Yoshihiko Tanno
    • 7
  • Shigeki Aoki
    • 3
  • Nobumasa Kato
    • 2
  • Kiyoto Kasai
    • 2
  1. 1.Department of Rehabilitation, Graduate school of MedicineThe University of TokyoTokyoJapan
  2. 2.Department of Neuropsychiatry, Graduate school of MedicineThe University of TokyoTokyoJapan
  3. 3.Department of Radiology, Graduate school of MedicineThe University of TokyoTokyoJapan
  4. 4.Department of NeuropsychiatrySaitama Medical SchoolSaitamaJapan
  5. 5.Department of Psychiatry, Graduate School of MedicineYokohama City UniversityYokohamaJapan
  6. 6.Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton DivisionHarvard Medical SchoolBostonUSA
  7. 7.Department of Life Sciences, Graduate school of Arts and SciencesThe University of TokyoTokyoJapan

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