Insight and regional brain volumes in schizophrenia

  • Débora Pastore Bassitt
  • Mario Rodrigues Louzã Neto
  • Cláudio Campi de Castro
  • Geraldo F. Busatto
ORIGINAL PAPER

DOI: 10.1007/s00406-006-0685-z

Cite this article as:
Bassitt, D.P., Neto, M.R.L., de Castro, C.C. et al. Eur Arch Psychiatry Clin Neurosci (2007) 257: 58. doi:10.1007/s00406-006-0685-z

Abstract

We have investigated the relationship between insight impairment and regional brain volumes (gray and white matter) in schizophrenia using voxel-based morphometry (VBM). Fifty patients with schizophrenia were evaluated using the Scale for Unawareness of Mental Disorders. Magnetic resonance images were acquired, segmented and spatially normalized using optimized VBM routines. No significant inverse correlations were detected between insight impairment and gray or white matter volumes in the prefrontal region (where significant findings had been predicted a priori), or in any other brain areas. Our results do not support previous hypotheses suggesting a relationship between frontal lobe atrophy and impaired insight in patients with schizophrenia.

Keywords

gray matter volume insight magnetic resonance schizophrenia 

Copyright information

© Steinkopff Verlag Darmstadt 2006

Authors and Affiliations

  • Débora Pastore Bassitt
    • 1
  • Mario Rodrigues Louzã Neto
    • 1
  • Cláudio Campi de Castro
    • 2
  • Geraldo F. Busatto
    • 1
  1. 1.Institute of Psychiatry, University of São Paulo, School of MedicineSão PauloBrazil
  2. 2.Magnetic Ressonance Imaging Section, Heart Institute, University of São Paulo, School of MedicineSão PauloBrazil

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